Preparation of injectable temperature-sensitive chitosan-based hydrogel for combined hyperthermia and chemotherapy of colon cancer

• Published in: Carbohydrate polymers 2019-10, Vol.222, p.115039-115039, Article 115039
• Main Authors: Zheng, Yuting, Wang, Weifan, Zhao, Jiulong, Wu, Chenyao, Ye, Changqing, Huang, Mingxian, Wang, Shige
• Format: Article
• Language: English
• Subjects: Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - therapeutic use; Bismuth - administration & dosage; Cell Line; Chemotherapy; Chitosan - administration & dosage; Chitosan - chemistry; Chitosan - pharmacology; Colonic Neoplasms - drug therapy; Disulfides - administration & dosage; Disulfides - radiation effects; Doxorubicin - administration & dosage; Doxorubicin - therapeutic use; Drug Carriers - administration & dosage; Drug Carriers - chemistry; Drug Carriers - pharmacology; Drug Liberation; Escherichia coli - drug effects; Hydrogel; Hydrogels - administration & dosage; Hydrogels - chemistry; Hydrogels - pharmacology; Hyperthermia, Induced - methods; Infrared Rays; Injections; Mice, Inbred BALB C; Molybdenum - administration & dosage; Molybdenum - radiation effects; NIR I and NIR II; Polyethylene Glycols - administration & dosage; Polyethylene Glycols - chemistry; Sulfides - administration & dosage; Sulfides - radiation effects; Temperature; Temperature-sensitive; Tumor hyperthermia; Xenograft Model Antitumor Assays
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2019.115039

•Chitosan-based composite hydrogel was designed for the synergistic photothermal- and chemotherapy of colon cancer.•The temperature-sensitive hydrogel could release drug in an on-demand manner.•Localized therapy with no harm to normal tissues and organs was achieved.•The chitosan-based hydrogel had antibacterial effects. The purpose of this study was to design an injectable hydrogel with temperature-sensitive property for safe and high efficient in vivo colon cancer hyperthermia and chemotherapy. Chitosan (CS) solution was injected into the tumor at room temperature and automatically gelled after warming to body temperature in the present of β-glycerophosphate (β-GP). Combined localized tumor photothermal and chemotherapy were achieved by dissolving photothermal material MoS2/Bi2S3-PEG (MBP) nanosheets and drug molecule doxorubicin (DOX) into the hydrogel, and the gel system could encapsulate DOX and MBP nanosheets and prevent them from entering the blood circulation and damaging normal tissues and cells. More importantly, the CS/MBP/DOX (CMD) hydrogel exhibited a photothermal efficiency of 22.18% and 31.42% in the first and second near infrared light (NIR I and NIR II) biowindows respectively at a low MBP concentration (0.5 mg/mL). Besides, the release of the DOX from CMD hydrogel was controllable since the gel temperature could be governed by NIR laser irradiation. Moreover, the chitosan-based hydrogel had antibacterial effects. The designed composite hydrogel is anticipated to act as a platform for the high efficient treatment of tumors owing to the different penetration depths of NIR I and NIR II.