Characteristics and pregnancy outcomes across gestational diabetes mellitus subtypes based on insulin resistance

Aims/hypothesis This study aimed to determine the characteristics and pregnancy outcomes across different subtypes of gestational diabetes mellitus (GDM) based on insulin resistance. Methods GDM subtypes were defined in 1813 pregnant women from a multicentre prospective cohort study, stratified acco...

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Bibliographic Details
Published in:Diabetologia 2019-11, Vol.62 (11), p.2118-2128
Main Authors: Benhalima, Katrien, Van Crombrugge, Paul, Moyson, Carolien, Verhaeghe, Johan, Vandeginste, Sofie, Verlaenen, Hilde, Vercammen, Chris, Maes, Toon, Dufraimont, Els, De Block, Christophe, Jacquemyn, Yves, Mekahli, Farah, De Clippel, Katrien, Van Den Bruel, Annick, Loccufier, Anne, Laenen, Annouschka, Minschart, Caro, Devlieger, Roland, Mathieu, Chantal
Format: Article
Language:English
Subjects:
Cholesterol
Demography
Diabetes
Diabetes mellitus
Fasting
Gestation
Gestational diabetes
Glucose
Glucose tolerance
Health risk assessment
Human Physiology
Hypoglycemia
Insulin
Insulin resistance
Internal Medicine
Intolerance
Laboratory testing
Low density lipoprotein
Medicine
Medicine & Public Health
Metabolic Diseases
Neonates
Postpartum
Pregnancy
Regression analysis
Womens health
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Summary:Aims/hypothesis This study aimed to determine the characteristics and pregnancy outcomes across different subtypes of gestational diabetes mellitus (GDM) based on insulin resistance. Methods GDM subtypes were defined in 1813 pregnant women from a multicentre prospective cohort study, stratified according to insulin resistance, based on Matsuda index below the 50th percentile of women with normal glucose tolerance (NGT), during a 75 g OGTT at 24–28 weeks’ gestation. GDM was diagnosed in 12.4% ( n  = 228) of all participants based on the 2013 WHO criteria. Results Compared with women with NGT (1113 [61.4%] of the total cohort) and insulin-sensitive women with GDM (39 [17.1%] women with GDM), women with GDM and high insulin resistance (189 [82.9%] women with GDM) had a significantly higher BMI, systolic BP, fasting plasma glucose (FPG), fasting total cholesterol, LDL-cholesterol and triacylglycerol levels in early pregnancy. Compared with women with NGT, insulin-sensitive women with GDM had a significantly lower BMI but similar BP, FPG and fasting lipid levels in early pregnancy. Compared with women with NGT, women with GDM and high insulin resistance had higher rates of preterm delivery (8.5% vs 4.7%, p  = 0.030), labour induction (42.7% vs 28.1%, p  
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-019-4961-7