Cognitive Rehabilitation Improves Ischemic Stroke-Induced Cognitive Impairment: Role of Growth Factors

Cognitive dysfunction is the most common nonphysical impairment in the stroke survivors. This impairment has a negative impact on patients’ quality of life affects their daily living activities. Both pharmacological and nonpharmacological interventions are employed to improve cognitive impairment. R...

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Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2019-10, Vol.28 (10), p.104299-104299, Article 104299
Main Authors: Farokhi-Sisakht, Fatemeh, Farhoudi, Mehdi, Sadigh-Eteghad, Saeed, Mahmoudi, Javad, Mohaddes, Gisou
Format: Article
Language:English
Subjects:
Animals
Brain - drug effects
Brain - metabolism
Brain - physiopathology
Brain Ischemia - metabolism
Brain Ischemia - physiopathology
Brain Ischemia - psychology
Brain Ischemia - rehabilitation
cognition
Cognition - drug effects
Cognitive Behavioral Therapy
Cognitive Dysfunction - metabolism
Cognitive Dysfunction - physiopathology
Cognitive Dysfunction - psychology
Cognitive Dysfunction - rehabilitation
cognitive rehabilitation
growth factors
Humans
Intercellular Signaling Peptides and Proteins - metabolism
Intercellular Signaling Peptides and Proteins - therapeutic use
Ischemic stroke
Neuronal Plasticity - drug effects
Recovery of Function
Stroke - metabolism
Stroke - physiopathology
Stroke - psychology
Stroke - therapy
Stroke Rehabilitation - methods
Treatment Outcome
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Summary:Cognitive dysfunction is the most common nonphysical impairment in the stroke survivors. This impairment has a negative impact on patients’ quality of life affects their daily living activities. Both pharmacological and nonpharmacological interventions are employed to improve cognitive impairment. Recently, nonpharmacological interventions have attracted great attention. Cognitive rehabilitation is considered as a therapeutic strategy to improve and maintain cognitive skills in patients with stroke. Enriched environment (EE), as a cognitive rehabilitation strategy, has been shown to facilitate physical, cognitive, as well as social abilities. Moreover, EE has been shown to increase endogenous growth factors. Growth factors have pivotal role in neurogenesis, synaptogenesis, as well as brain remodeling through neuron development, differentiation, and survival. In addition, administration of exogenous growth factors prevents cognitive dysfunction. Here, we review preclinical and clinical evidence of cognitive rehabilitation and role of growth factors in treating poststroke cognitive impairment.
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2019.07.015