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Synthesis, characterization and pharmacological potential of green synthesized copper nanoparticles
The phenomenal and astonishing properties and their different application in the field of pharmaceutical made copper nanoparticles (Cu-NPs) to be in the spotlight of the researcher's focus. In the present study, copper nanoparticles were biologically synthesized with the aqueous extract of the...
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| Published in: | Bioprocess and biosystems engineering 2019-11, Vol.42 (11), p.1769-1777 |
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| container_issue | 11 |
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| container_title | Bioprocess and biosystems engineering |
| container_volume | 42 |
| creator | Thiruvengadam, Muthu Chung, Ill-Min Gomathi, Thandapani Ansari, Mohammad Azam Gopiesh Khanna, Venkatesan Babu, Vaishnavi Rajakumar, Govindasamy |
| description | The phenomenal and astonishing properties and their different application in the field of pharmaceutical made copper nanoparticles (Cu-NPs) to be in the spotlight of the researcher's focus. In the present study, copper nanoparticles were biologically synthesized with the aqueous extract of the flower
Millettia pinnata
, and their corresponding characteristics were studied using UV–visible spectroscopy, XRD, FT-IR, SEM, TEM, and SAED analysis. Copper acetate was reduced to copper nanoparticles and is confirmed by UV–visible spectrophotometer analysis. The maximum absorption occurring at 384 nm at the visible spectrum of UV rays confirms the surface plasmon resonance of the nanoparticles. The result of the FTIR spectroscopy analysis of the nanoparticles complements the involvement of organic mioties of the flower extract in the synthesis. The synthesized particles were extremely durable, spherical with the average particle size in the range of 23 ± 1.10 nm. The Cu-NPs exhibited greater inhibition on DPPH radical and nitric oxide scavenging activities. The biologically synthesized Cu-NPs was receptive to the Gram-negative and Gram-positive bacteria as well. The Cu-NPs exhibited strong anti-inflammatory activity using albumin denaturation and membrane stabilization. The present study is the first effort done to synthesize of Cu-NPs from the extract of
M. pinnata
flower. Consequently, to authenticate the results and to establish the antioxidant, antibacterial, an anti-diabetic and anti-inflammatory agent, in vivo studies are made in the molecular level. |
| doi_str_mv | 10.1007/s00449-019-02173-y |
| format | article |
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Millettia pinnata
, and their corresponding characteristics were studied using UV–visible spectroscopy, XRD, FT-IR, SEM, TEM, and SAED analysis. Copper acetate was reduced to copper nanoparticles and is confirmed by UV–visible spectrophotometer analysis. The maximum absorption occurring at 384 nm at the visible spectrum of UV rays confirms the surface plasmon resonance of the nanoparticles. The result of the FTIR spectroscopy analysis of the nanoparticles complements the involvement of organic mioties of the flower extract in the synthesis. The synthesized particles were extremely durable, spherical with the average particle size in the range of 23 ± 1.10 nm. The Cu-NPs exhibited greater inhibition on DPPH radical and nitric oxide scavenging activities. The biologically synthesized Cu-NPs was receptive to the Gram-negative and Gram-positive bacteria as well. The Cu-NPs exhibited strong anti-inflammatory activity using albumin denaturation and membrane stabilization. The present study is the first effort done to synthesize of Cu-NPs from the extract of
M. pinnata
flower. Consequently, to authenticate the results and to establish the antioxidant, antibacterial, an anti-diabetic and anti-inflammatory agent, in vivo studies are made in the molecular level.</description><identifier>ISSN: 1615-7591</identifier><identifier>EISSN: 1615-7605</identifier><identifier>DOI: 10.1007/s00449-019-02173-y</identifier><identifier>PMID: 31372759</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acetic acid ; Anti-Bacterial Agents - chemical synthesis ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Anti-inflammatory agents ; Anti-Inflammatory Agents - chemical synthesis ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - pharmacology ; Antioxidants ; Antioxidants - chemical synthesis ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Bacteria ; Biotechnology ; Chemistry ; Chemistry and Materials Science ; Copper ; Copper - chemistry ; Copper - pharmacology ; Denaturation ; Diabetes mellitus ; Environmental Engineering/Biotechnology ; Flowers ; Flowers - chemistry ; Food Science ; Fourier transforms ; Gram-positive bacteria ; Green Chemistry Technology ; Hypoglycemic Agents - chemical synthesis ; Hypoglycemic Agents - chemistry ; Hypoglycemic Agents - pharmacology ; In vivo methods and tests ; Industrial and Production Engineering ; Industrial Chemistry/Chemical Engineering ; Inflammation ; Infrared spectroscopy ; Metal Nanoparticles - chemistry ; Millettia - chemistry ; Nanoparticles ; Nitric oxide ; Particle Size ; Pharmacology ; Plant Extracts - chemistry ; Research Paper ; Scavenging ; Spectroscopy ; Spectrum analysis ; Surface plasmon resonance ; Synthesis ; Visible spectrum</subject><ispartof>Bioprocess and biosystems engineering, 2019-11, Vol.42 (11), p.1769-1777</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>Bioprocess and Biosystems Engineering is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-9d2022f166e498606fcf7fa758f08caf3eb9c7a081e076ed0f41babebc4edd093</citedby><cites>FETCH-LOGICAL-c412t-9d2022f166e498606fcf7fa758f08caf3eb9c7a081e076ed0f41babebc4edd093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31372759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thiruvengadam, Muthu</creatorcontrib><creatorcontrib>Chung, Ill-Min</creatorcontrib><creatorcontrib>Gomathi, Thandapani</creatorcontrib><creatorcontrib>Ansari, Mohammad Azam</creatorcontrib><creatorcontrib>Gopiesh Khanna, Venkatesan</creatorcontrib><creatorcontrib>Babu, Vaishnavi</creatorcontrib><creatorcontrib>Rajakumar, Govindasamy</creatorcontrib><title>Synthesis, characterization and pharmacological potential of green synthesized copper nanoparticles</title><title>Bioprocess and biosystems engineering</title><addtitle>Bioprocess Biosyst Eng</addtitle><addtitle>Bioprocess Biosyst Eng</addtitle><description>The phenomenal and astonishing properties and their different application in the field of pharmaceutical made copper nanoparticles (Cu-NPs) to be in the spotlight of the researcher's focus. In the present study, copper nanoparticles were biologically synthesized with the aqueous extract of the flower
Millettia pinnata
, and their corresponding characteristics were studied using UV–visible spectroscopy, XRD, FT-IR, SEM, TEM, and SAED analysis. Copper acetate was reduced to copper nanoparticles and is confirmed by UV–visible spectrophotometer analysis. The maximum absorption occurring at 384 nm at the visible spectrum of UV rays confirms the surface plasmon resonance of the nanoparticles. The result of the FTIR spectroscopy analysis of the nanoparticles complements the involvement of organic mioties of the flower extract in the synthesis. The synthesized particles were extremely durable, spherical with the average particle size in the range of 23 ± 1.10 nm. The Cu-NPs exhibited greater inhibition on DPPH radical and nitric oxide scavenging activities. The biologically synthesized Cu-NPs was receptive to the Gram-negative and Gram-positive bacteria as well. The Cu-NPs exhibited strong anti-inflammatory activity using albumin denaturation and membrane stabilization. The present study is the first effort done to synthesize of Cu-NPs from the extract of
M. pinnata
flower. Consequently, to authenticate the results and to establish the antioxidant, antibacterial, an anti-diabetic and anti-inflammatory agent, in vivo studies are made in the molecular level.</description><subject>Acetic acid</subject><subject>Anti-Bacterial Agents - chemical synthesis</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-inflammatory agents</subject><subject>Anti-Inflammatory Agents - chemical synthesis</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antioxidants</subject><subject>Antioxidants - chemical synthesis</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>Bacteria</subject><subject>Biotechnology</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Copper</subject><subject>Copper - chemistry</subject><subject>Copper - pharmacology</subject><subject>Denaturation</subject><subject>Diabetes mellitus</subject><subject>Environmental Engineering/Biotechnology</subject><subject>Flowers</subject><subject>Flowers - chemistry</subject><subject>Food Science</subject><subject>Fourier transforms</subject><subject>Gram-positive bacteria</subject><subject>Green Chemistry Technology</subject><subject>Hypoglycemic Agents - chemical synthesis</subject><subject>Hypoglycemic Agents - chemistry</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>In vivo methods and tests</subject><subject>Industrial and Production Engineering</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Inflammation</subject><subject>Infrared spectroscopy</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Millettia - chemistry</subject><subject>Nanoparticles</subject><subject>Nitric oxide</subject><subject>Particle Size</subject><subject>Pharmacology</subject><subject>Plant Extracts - chemistry</subject><subject>Research Paper</subject><subject>Scavenging</subject><subject>Spectroscopy</subject><subject>Spectrum analysis</subject><subject>Surface plasmon resonance</subject><subject>Synthesis</subject><subject>Visible spectrum</subject><issn>1615-7591</issn><issn>1615-7605</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kT1PxDAMhiME4vsPMKBKLAwU7LRN2xGd-JKQGIA5SlPnKOolJekNx68nx92BxMBg2Yofv478MnaCcIkA5VUAyPM6BYzBsczSxRbbR4FFWgootjd1UeMeOwjhHQCLisMu28swK3ls7DP9vLDjG4UuXCT6TXmlR_Ldpxo7ZxNl22SIjzOlXe-mnVZ9MriR7NjFyplk6olsEtYSn9Qm2g0D-cQq6wblx073FI7YjlF9oON1PmSvtzcvk_v08enuYXL9mOoc-ZjWLQfODQpBeV0JEEab0qiyqAxUWpmMmlqXCiokKAW1YHJsVEONzqltoc4O2flKd_DuY05hlLMuaOp7ZcnNg-RcVBkiQhbRsz_ou5t7G3-3pOJlOKKIFF9R2rsQPBk5-G6m_EIiyKUFcmWBjBbIbwvkIg6drqXnzYzan5HNzSOQrYAQW3ZK_nf3P7JfJ2WUew</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Thiruvengadam, Muthu</creator><creator>Chung, Ill-Min</creator><creator>Gomathi, Thandapani</creator><creator>Ansari, Mohammad Azam</creator><creator>Gopiesh Khanna, Venkatesan</creator><creator>Babu, Vaishnavi</creator><creator>Rajakumar, Govindasamy</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20191101</creationdate><title>Synthesis, characterization and pharmacological potential of green synthesized copper nanoparticles</title><author>Thiruvengadam, Muthu ; Chung, Ill-Min ; Gomathi, Thandapani ; Ansari, Mohammad Azam ; Gopiesh Khanna, Venkatesan ; Babu, Vaishnavi ; Rajakumar, Govindasamy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-9d2022f166e498606fcf7fa758f08caf3eb9c7a081e076ed0f41babebc4edd093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acetic acid</topic><topic>Anti-Bacterial Agents - 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Academic</collection><jtitle>Bioprocess and biosystems engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thiruvengadam, Muthu</au><au>Chung, Ill-Min</au><au>Gomathi, Thandapani</au><au>Ansari, Mohammad Azam</au><au>Gopiesh Khanna, Venkatesan</au><au>Babu, Vaishnavi</au><au>Rajakumar, Govindasamy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, characterization and pharmacological potential of green synthesized copper nanoparticles</atitle><jtitle>Bioprocess and biosystems engineering</jtitle><stitle>Bioprocess Biosyst Eng</stitle><addtitle>Bioprocess Biosyst Eng</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>42</volume><issue>11</issue><spage>1769</spage><epage>1777</epage><pages>1769-1777</pages><issn>1615-7591</issn><eissn>1615-7605</eissn><abstract>The phenomenal and astonishing properties and their different application in the field of pharmaceutical made copper nanoparticles (Cu-NPs) to be in the spotlight of the researcher's focus. In the present study, copper nanoparticles were biologically synthesized with the aqueous extract of the flower
Millettia pinnata
, and their corresponding characteristics were studied using UV–visible spectroscopy, XRD, FT-IR, SEM, TEM, and SAED analysis. Copper acetate was reduced to copper nanoparticles and is confirmed by UV–visible spectrophotometer analysis. The maximum absorption occurring at 384 nm at the visible spectrum of UV rays confirms the surface plasmon resonance of the nanoparticles. The result of the FTIR spectroscopy analysis of the nanoparticles complements the involvement of organic mioties of the flower extract in the synthesis. The synthesized particles were extremely durable, spherical with the average particle size in the range of 23 ± 1.10 nm. The Cu-NPs exhibited greater inhibition on DPPH radical and nitric oxide scavenging activities. The biologically synthesized Cu-NPs was receptive to the Gram-negative and Gram-positive bacteria as well. The Cu-NPs exhibited strong anti-inflammatory activity using albumin denaturation and membrane stabilization. The present study is the first effort done to synthesize of Cu-NPs from the extract of
M. pinnata
flower. Consequently, to authenticate the results and to establish the antioxidant, antibacterial, an anti-diabetic and anti-inflammatory agent, in vivo studies are made in the molecular level.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31372759</pmid><doi>10.1007/s00449-019-02173-y</doi><tpages>9</tpages></addata></record> |
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| source | Springer Nature |
| subjects | Acetic acid Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-inflammatory agents Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Antioxidants Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - pharmacology Bacteria Biotechnology Chemistry Chemistry and Materials Science Copper Copper - chemistry Copper - pharmacology Denaturation Diabetes mellitus Environmental Engineering/Biotechnology Flowers Flowers - chemistry Food Science Fourier transforms Gram-positive bacteria Green Chemistry Technology Hypoglycemic Agents - chemical synthesis Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology In vivo methods and tests Industrial and Production Engineering Industrial Chemistry/Chemical Engineering Inflammation Infrared spectroscopy Metal Nanoparticles - chemistry Millettia - chemistry Nanoparticles Nitric oxide Particle Size Pharmacology Plant Extracts - chemistry Research Paper Scavenging Spectroscopy Spectrum analysis Surface plasmon resonance Synthesis Visible spectrum |
| title | Synthesis, characterization and pharmacological potential of green synthesized copper nanoparticles |
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