A Changing Etiologic Scenario in Liver Transplantation: A Single-Center Cohort Study From Turkey

Nonalcoholic steatohepatitis (NASH) is an increasing cause of liver transplantation (LT) worldwide, especially in Europe and North America. In this study, we aimed to investigate the changing pattern of etiologic causes of LT in our center for the past 15 years. A cohort of 967 consecutive adult pat...

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Bibliographic Details
Published in:Transplantation proceedings 2019-09, Vol.51 (7), p.2416-2419
Main Authors: Serin, Ayfer, Sahin, Tolga, Arikan, Bahadir Turkmen, Emek, Ertan, Bozkurt, Birkan, Tokat, Yaman
Format: Article
Language:English
Subjects:
Adult
Cohort Studies
Female
Hepatitis B, Chronic - epidemiology
Hepatitis B, Chronic - surgery
Hepatitis C - epidemiology
Hepatitis C - surgery
Humans
Liver Diseases, Alcoholic - epidemiology
Liver Diseases, Alcoholic - surgery
Liver Transplantation - statistics & numerical data
Male
Middle Aged
Non-alcoholic Fatty Liver Disease - epidemiology
Non-alcoholic Fatty Liver Disease - surgery
Turkey
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Summary:Nonalcoholic steatohepatitis (NASH) is an increasing cause of liver transplantation (LT) worldwide, especially in Europe and North America. In this study, we aimed to investigate the changing pattern of etiologic causes of LT in our center for the past 15 years. A cohort of 967 consecutive adult patients with history of LT between 2004 and 2018 in our center was reviewed regarding etiologies for LT. All patients who had a transplant during this time frame were divided into 3 time periods as follows: 2004 to 2009, 2010 to 2013, and 2014 to 2018. All explanted liver samples were sent to pathology for establishment of a definitive etiologic cause. Chronic hepatitis B virus (HBV) infection was the leading cause of LT in the overall cohort (37%), followed by hepatitis C virus (HCV) infection (11%), and alcoholic liver disease (9.5%). NASH accounted for 7.5% of the cases. While HBV decreased from 44% in 2004 to 2009 to 36% in 2014 to 2018, NASH increased from 1.1% to 9.4% in overall transplants during the same period, accounting for one-third of the etiologies for LT following HBV and HCV. There might be a global changing figure regarding etiology for LT in Turkey, especially NASH, which is the fastest growing cause of LT. However, this topic needs to be evaluated in large cohort series from collaborative multicenter studies from Turkey.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2019.01.190