Dexmedetomidine Alleviates Postpartum Depressive Symptoms following Cesarean Section in Chinese Women: A Randomized Placebo‐Controlled Study

Objectives Few studies have investigated the prophylactic efficacy of dexmedetomidine (DEX) in postpartum depressive symptoms (PDS). A randomized double‐blind placebo‐controlled trial was conducted to investigate whether the administration of DEX, immediately after delivery and for patient‐controlle...

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Bibliographic Details
Published in:Pharmacotherapy 2019-10, Vol.39 (10), p.994-1004
Main Authors: Yu, He‐Ya, Wang, Sai‐Ying, Quan, Cheng‐Xuan, Fang, Chao, Luo, Shi‐Chao, Li, Dan‐Yang, Zhen, Shan‐Shan, Ma, Jia‐Hui, Duan, Kai‐Ming
Format: Article
Language:English
Subjects:
Analgesia
Anesthesia
Cesarean section
dexmedetomidine
Health risk assessment
Incidence
Intravenous administration
Mental depression
Mental disorders
Pain perception
Postpartum
Postpartum depression
postpartum depressive symptoms
Pregnancy
Prenatal depression
Randomization
Sleep
Sufentanil
α2‐Adrenoceptor
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Summary:Objectives Few studies have investigated the prophylactic efficacy of dexmedetomidine (DEX) in postpartum depressive symptoms (PDS). A randomized double‐blind placebo‐controlled trial was conducted to investigate whether the administration of DEX, immediately after delivery and for patient‐controlled intravenous analgesia (PCIA), can attenuate PDS. Methods A total of 600 parturients scheduled for elective cesarean delivery under spinal anesthesia were randomly allocated into the control group (infusion with 0.9% normal saline after delivery and PCIA with sufentanil) and the DEX group (DEX infusion 0.5 μg/kg after delivery and PCIA with DEX plus sufentanil). The prevalence of postpartum depressive disorders was indicated by the Edinburgh Postnatal Depression Scale (EPDS). Postoperative analgesia, sedation, and sleep quality of parturients were also assessed. Results Postpartum blues and PDS prevalence in the DEX, versus control, group were significantly lower (5.0% vs 14.1%, p
ISSN:0277-0008
1875-9114
DOI:10.1002/phar.2320