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Validation of the Guy's Neurological Disability Scale as a screening tool for cognitive impairment in multiple sclerosis
•Scores from Japanese version of GNDS were validated in MS patients.•GNDS-J scores correlated with EDSS, PASAT, and SDMT scores.•GNDS-J-score exacerbation reflected clinical relapses.•GNDS-J scores provide a comprehensive disability status of Japanese MS patients. Cognitive impairment is a common sy...
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Published in: | Multiple sclerosis and related disorders 2019-10, Vol.35, p.272-275 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | •Scores from Japanese version of GNDS were validated in MS patients.•GNDS-J scores correlated with EDSS, PASAT, and SDMT scores.•GNDS-J-score exacerbation reflected clinical relapses.•GNDS-J scores provide a comprehensive disability status of Japanese MS patients.
Cognitive impairment is a common symptom affecting daily activities of the patients with multiple sclerosis (MS). Various cognitive evaluation tests are available, yet most of them are complex and time-consuming to perform in outpatient clinics. In this study, we aimed to validate a Japanese version of the Guy's Neurological Disability Scale (GNDS) as a user-friendly tool to evaluate comprehensive disabilities in MS including cognitive function.
Questions of the GNDS were translated into Japanese and named GNDS-J. Forty-four patients were examined by the Expanded Disability Status Scale (EDSS), the Paced Auditory Serial Addition Test (PASAT), the Symbol Digit Modalities Test (SDMT), the vitality scale, and the GNDS-J in the same time at remission state.
The GNDS-J scores correlated with the EDSS scores(r = 0.61), and inversely correlated with the PASAT2/1(r=-0.56/-0.49) scores and the SDMT scores (r=-0.68), whereas the GNDS-J did not show any correlation with the vitality scale. Furthermore, eleven patients were evaluated over 5 years for changes in these scores. Eight out of 11 patients had exacerbated GNDS, and all of these patients experienced clinical relapse during this period.
The GNDS-J is a valid tool to perform in outpatient clinics, which could provide a comprehensive scale for evaluating symptoms of MS, thus the disease activity by repeated measure. |
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ISSN: | 2211-0348 2211-0356 |
DOI: | 10.1016/j.msard.2019.08.012 |