Visible‐Light‐Promoted Cascade Radical Cyclization: Synthesis of 1,4‐Diketones Containing Chroman‐4‐One Skeletons

A visible‐light‐induced cascade radical cyclization of aroyl chlorides with 2‐(allyloxy)‐benzaldehyde derivatives has been developed. The method takes advantages of unactivated C=C bonds as the acyl radical acceptors and offers a mild and green approach for the synthesis of 1,4‐diketones bearing bio...

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Bibliographic Details
Published in:Chemistry, an Asian journal an Asian journal, 2019-10, Vol.14 (19), p.3269-3273
Main Authors: He, Xiang‐Kui, Cai, Bao‐Gui, Yang, Qing‐Qing, Wang, Long, Xuan, Jun
Format: Article
Language:English
Subjects:
1,4-Diketones
Acyl radical
Benzaldehyde
Chemistry
Diketones
Photoredox catalysis
Radical cyclization
Synthesis
Visible light
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Summary:A visible‐light‐induced cascade radical cyclization of aroyl chlorides with 2‐(allyloxy)‐benzaldehyde derivatives has been developed. The method takes advantages of unactivated C=C bonds as the acyl radical acceptors and offers a mild and green approach for the synthesis of 1,4‐diketones bearing biologically important chroman‐4‐one skeletons with moderate to good yields. A visible‐light‐induced cascade radical cyclization of aroyl chlorides with 2‐(allyloxy)‐benzaldehyde derivatives has been developed. The method takes advantage of unactivated C=C bonds as the acyl radical acceptors and offers a mild and green approach for the synthesis of 1,4‐diketones bearing biologically important chroman‐4‐one skeletons in moderate to good yields.
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.201901078