Copper-Catalyzed Regioselective sp3 C–H Azidation of Alkyl Substituents of Indoles and Tetrahydrocarbazoles

An efficient regioselective sp3 C–H azidation is developed using CuBr as the catalyst and Zhdankin azidoiodinane as the “N3” source. Under simple and mild reaction conditions, the azido group could be successfully incorporated into the sp3 C–H alkyl substituents of indoles and tetrahydrocarbazoles....

Full description

Saved in:
Bibliographic Details
Published in:Journal of organic chemistry 2019-09, Vol.84 (18), p.11885-11890
Main Authors: Huang, Liwu, Xun, Xudong, Zhao, Man, Xue, Jianzhong, Li, Guofeng, Hong, Liang
Format: Article
Language:eng ; jpn
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An efficient regioselective sp3 C–H azidation is developed using CuBr as the catalyst and Zhdankin azidoiodinane as the “N3” source. Under simple and mild reaction conditions, the azido group could be successfully incorporated into the sp3 C–H alkyl substituents of indoles and tetrahydrocarbazoles.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.9b01742