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Lower fecal pH may be a novel indicator of pouchitis after IPAA in patients with FAP or metachronous Lynch syndrome
Background and Objectives To assess whether fecal pH might be an indicator of pouchitis during the postoperative period in hereditary colorectal cancer (CRC) patients who have undergone ileal pouch anal anastomosis (IPAA). Methods Five consecutive daily pH values of stool samples from 31 familial ad...
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| Published in: | Journal of surgical oncology 2019-12, Vol.120 (7), p.1184-1189 |
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| container_end_page | 1189 |
| container_issue | 7 |
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| container_title | Journal of surgical oncology |
| container_volume | 120 |
| creator | Yang, Liu Bao, Jun Jiang, Qian Yu, Dong‐sheng Zhong, Jian |
| description | Background and Objectives
To assess whether fecal pH might be an indicator of pouchitis during the postoperative period in hereditary colorectal cancer (CRC) patients who have undergone ileal pouch anal anastomosis (IPAA).
Methods
Five consecutive daily pH values of stool samples from 31 familial adenomatous polyposis (FAP) patients and 32 metachronous Lynch syndrome patients who underwent IPAA procedures were reviewed. Patients with pouchitis (pouchitis group, n = 22) were compared with patients without pouchitis (nonpouchitis group, n = 41). A receiver operating characteristic (ROC) analysis was performed to determine the indicative potential of fecal pH for pouchitis. A Mantel‐Cox test was also performed to evaluate the survival status of patients with or without pouchitis.
Results
Pouchitis was noted in 22 (34.9%) of 63 patients after IPAA. The significance of each daily average fecal pH value and the 5‐day overall average fecal pH value was compared between the two groups (P |
| doi_str_mv | 10.1002/jso.25699 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2283986212</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2283986212</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3139-1cb2e3780d3babc601da9e345cd0678b6177317b0f9f9f85a298905a7998b1473</originalsourceid><addsrcrecordid>eNp10U9v2yAYBnBUbVrTdod-gQlpl_Xg5gVim_cYVes_RWqkrWeEMVaIbOOB3cjfvnTpdpg0ceDAj0cvPIRcMrhmAHy5j_6a5wXiCVkwwCJDQPmBLNIZz1Ylwik5i3EPAIjF6hM5FWxVSg58QeLGH2ygjTW6pcM97fRMK0s17f2Lbanra2f06AP1DR38ZHZudJHqZkyXHrbrdRJ00KOz_RjpwY07erve0uQ7O2qzC773U6SbuTc7Gue-Dr6zF-Rjo9toP7_v5-T59vvPm_ts83T3cLPeZEYwgRkzFbeilFCLSlemAFZrtGKVmxqKUlYFK0vBygoaTEvmmqNEyHWJKKv0QHFOvh1zh-B_TTaOqnPR2LbVvU1TKc6lQFlwxhP9-g_d-yn0aTrFBSBHgBySujoqE3yMwTZqCK7TYVYM1FsTKjWhfjeR7Jf3xKnqbP1X_vn6BJZHcHCtnf-fpB5_PB0jXwHPtZEO</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2309290050</pqid></control><display><type>article</type><title>Lower fecal pH may be a novel indicator of pouchitis after IPAA in patients with FAP or metachronous Lynch syndrome</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Yang, Liu ; Bao, Jun ; Jiang, Qian ; Yu, Dong‐sheng ; Zhong, Jian</creator><creatorcontrib>Yang, Liu ; Bao, Jun ; Jiang, Qian ; Yu, Dong‐sheng ; Zhong, Jian</creatorcontrib><description>Background and Objectives
To assess whether fecal pH might be an indicator of pouchitis during the postoperative period in hereditary colorectal cancer (CRC) patients who have undergone ileal pouch anal anastomosis (IPAA).
Methods
Five consecutive daily pH values of stool samples from 31 familial adenomatous polyposis (FAP) patients and 32 metachronous Lynch syndrome patients who underwent IPAA procedures were reviewed. Patients with pouchitis (pouchitis group, n = 22) were compared with patients without pouchitis (nonpouchitis group, n = 41). A receiver operating characteristic (ROC) analysis was performed to determine the indicative potential of fecal pH for pouchitis. A Mantel‐Cox test was also performed to evaluate the survival status of patients with or without pouchitis.
Results
Pouchitis was noted in 22 (34.9%) of 63 patients after IPAA. The significance of each daily average fecal pH value and the 5‐day overall average fecal pH value was compared between the two groups (P < .01). A cutoff fecal pH value of 7.46 was determined by the ROC analysis for assessing the risk of pouchitis. No significant difference in 5‐year overall survival was observed between the two groups.
Conclusion
A lower fecal pH value in patients with hereditary CRC after IPAA might be a new indicator of pouchitis.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.25699</identifier><identifier>PMID: 31478202</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adenomatous Polyposis Coli - pathology ; Adenomatous Polyposis Coli - surgery ; Adult ; Cancer surgery ; Colorectal cancer ; Colorectal Neoplasms, Hereditary Nonpolyposis - pathology ; Colorectal Neoplasms, Hereditary Nonpolyposis - surgery ; Colorectal surgery ; Feces ; Feces - chemistry ; Female ; Follow-Up Studies ; Genetic disorders ; hereditary colorectal cancer ; Humans ; Hydrogen-Ion Concentration ; IPAA ; Male ; pH value ; Postoperative Complications ; pouchitis ; Pouchitis - diagnosis ; Pouchitis - etiology ; Proctocolectomy, Restorative - adverse effects ; Prognosis ; Retrospective Studies ; Survival Rate</subject><ispartof>Journal of surgical oncology, 2019-12, Vol.120 (7), p.1184-1189</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3139-1cb2e3780d3babc601da9e345cd0678b6177317b0f9f9f85a298905a7998b1473</cites><orcidid>0000-0002-5961-1469</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31478202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Liu</creatorcontrib><creatorcontrib>Bao, Jun</creatorcontrib><creatorcontrib>Jiang, Qian</creatorcontrib><creatorcontrib>Yu, Dong‐sheng</creatorcontrib><creatorcontrib>Zhong, Jian</creatorcontrib><title>Lower fecal pH may be a novel indicator of pouchitis after IPAA in patients with FAP or metachronous Lynch syndrome</title><title>Journal of surgical oncology</title><addtitle>J Surg Oncol</addtitle><description>Background and Objectives
To assess whether fecal pH might be an indicator of pouchitis during the postoperative period in hereditary colorectal cancer (CRC) patients who have undergone ileal pouch anal anastomosis (IPAA).
Methods
Five consecutive daily pH values of stool samples from 31 familial adenomatous polyposis (FAP) patients and 32 metachronous Lynch syndrome patients who underwent IPAA procedures were reviewed. Patients with pouchitis (pouchitis group, n = 22) were compared with patients without pouchitis (nonpouchitis group, n = 41). A receiver operating characteristic (ROC) analysis was performed to determine the indicative potential of fecal pH for pouchitis. A Mantel‐Cox test was also performed to evaluate the survival status of patients with or without pouchitis.
Results
Pouchitis was noted in 22 (34.9%) of 63 patients after IPAA. The significance of each daily average fecal pH value and the 5‐day overall average fecal pH value was compared between the two groups (P < .01). A cutoff fecal pH value of 7.46 was determined by the ROC analysis for assessing the risk of pouchitis. No significant difference in 5‐year overall survival was observed between the two groups.
Conclusion
A lower fecal pH value in patients with hereditary CRC after IPAA might be a new indicator of pouchitis.</description><subject>Adenomatous Polyposis Coli - pathology</subject><subject>Adenomatous Polyposis Coli - surgery</subject><subject>Adult</subject><subject>Cancer surgery</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms, Hereditary Nonpolyposis - pathology</subject><subject>Colorectal Neoplasms, Hereditary Nonpolyposis - surgery</subject><subject>Colorectal surgery</subject><subject>Feces</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Genetic disorders</subject><subject>hereditary colorectal cancer</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>IPAA</subject><subject>Male</subject><subject>pH value</subject><subject>Postoperative Complications</subject><subject>pouchitis</subject><subject>Pouchitis - diagnosis</subject><subject>Pouchitis - etiology</subject><subject>Proctocolectomy, Restorative - adverse effects</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp10U9v2yAYBnBUbVrTdod-gQlpl_Xg5gVim_cYVes_RWqkrWeEMVaIbOOB3cjfvnTpdpg0ceDAj0cvPIRcMrhmAHy5j_6a5wXiCVkwwCJDQPmBLNIZz1Ylwik5i3EPAIjF6hM5FWxVSg58QeLGH2ygjTW6pcM97fRMK0s17f2Lbanra2f06AP1DR38ZHZudJHqZkyXHrbrdRJ00KOz_RjpwY07erve0uQ7O2qzC773U6SbuTc7Gue-Dr6zF-Rjo9toP7_v5-T59vvPm_ts83T3cLPeZEYwgRkzFbeilFCLSlemAFZrtGKVmxqKUlYFK0vBygoaTEvmmqNEyHWJKKv0QHFOvh1zh-B_TTaOqnPR2LbVvU1TKc6lQFlwxhP9-g_d-yn0aTrFBSBHgBySujoqE3yMwTZqCK7TYVYM1FsTKjWhfjeR7Jf3xKnqbP1X_vn6BJZHcHCtnf-fpB5_PB0jXwHPtZEO</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Yang, Liu</creator><creator>Bao, Jun</creator><creator>Jiang, Qian</creator><creator>Yu, Dong‐sheng</creator><creator>Zhong, Jian</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5961-1469</orcidid></search><sort><creationdate>20191201</creationdate><title>Lower fecal pH may be a novel indicator of pouchitis after IPAA in patients with FAP or metachronous Lynch syndrome</title><author>Yang, Liu ; Bao, Jun ; Jiang, Qian ; Yu, Dong‐sheng ; Zhong, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3139-1cb2e3780d3babc601da9e345cd0678b6177317b0f9f9f85a298905a7998b1473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adenomatous Polyposis Coli - pathology</topic><topic>Adenomatous Polyposis Coli - surgery</topic><topic>Adult</topic><topic>Cancer surgery</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms, Hereditary Nonpolyposis - pathology</topic><topic>Colorectal Neoplasms, Hereditary Nonpolyposis - surgery</topic><topic>Colorectal surgery</topic><topic>Feces</topic><topic>Feces - chemistry</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Genetic disorders</topic><topic>hereditary colorectal cancer</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>IPAA</topic><topic>Male</topic><topic>pH value</topic><topic>Postoperative Complications</topic><topic>pouchitis</topic><topic>Pouchitis - diagnosis</topic><topic>Pouchitis - etiology</topic><topic>Proctocolectomy, Restorative - adverse effects</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Liu</creatorcontrib><creatorcontrib>Bao, Jun</creatorcontrib><creatorcontrib>Jiang, Qian</creatorcontrib><creatorcontrib>Yu, Dong‐sheng</creatorcontrib><creatorcontrib>Zhong, Jian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Liu</au><au>Bao, Jun</au><au>Jiang, Qian</au><au>Yu, Dong‐sheng</au><au>Zhong, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lower fecal pH may be a novel indicator of pouchitis after IPAA in patients with FAP or metachronous Lynch syndrome</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J Surg Oncol</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>120</volume><issue>7</issue><spage>1184</spage><epage>1189</epage><pages>1184-1189</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background and Objectives
To assess whether fecal pH might be an indicator of pouchitis during the postoperative period in hereditary colorectal cancer (CRC) patients who have undergone ileal pouch anal anastomosis (IPAA).
Methods
Five consecutive daily pH values of stool samples from 31 familial adenomatous polyposis (FAP) patients and 32 metachronous Lynch syndrome patients who underwent IPAA procedures were reviewed. Patients with pouchitis (pouchitis group, n = 22) were compared with patients without pouchitis (nonpouchitis group, n = 41). A receiver operating characteristic (ROC) analysis was performed to determine the indicative potential of fecal pH for pouchitis. A Mantel‐Cox test was also performed to evaluate the survival status of patients with or without pouchitis.
Results
Pouchitis was noted in 22 (34.9%) of 63 patients after IPAA. The significance of each daily average fecal pH value and the 5‐day overall average fecal pH value was compared between the two groups (P < .01). A cutoff fecal pH value of 7.46 was determined by the ROC analysis for assessing the risk of pouchitis. No significant difference in 5‐year overall survival was observed between the two groups.
Conclusion
A lower fecal pH value in patients with hereditary CRC after IPAA might be a new indicator of pouchitis.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31478202</pmid><doi>10.1002/jso.25699</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5961-1469</orcidid></addata></record> |
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| ispartof | Journal of surgical oncology, 2019-12, Vol.120 (7), p.1184-1189 |
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| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adenomatous Polyposis Coli - pathology Adenomatous Polyposis Coli - surgery Adult Cancer surgery Colorectal cancer Colorectal Neoplasms, Hereditary Nonpolyposis - pathology Colorectal Neoplasms, Hereditary Nonpolyposis - surgery Colorectal surgery Feces Feces - chemistry Female Follow-Up Studies Genetic disorders hereditary colorectal cancer Humans Hydrogen-Ion Concentration IPAA Male pH value Postoperative Complications pouchitis Pouchitis - diagnosis Pouchitis - etiology Proctocolectomy, Restorative - adverse effects Prognosis Retrospective Studies Survival Rate |
| title | Lower fecal pH may be a novel indicator of pouchitis after IPAA in patients with FAP or metachronous Lynch syndrome |
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