Risk scoring system with MRI for intraoperative massive hemorrhage in placenta previa and accreta

• Published in: Journal of magnetic resonance imaging 2020-03, Vol.51 (3), p.947-958
• Main Authors: Chen, Daijuan, Xu, Jinfeng, Ye, Pengfei, Li, Mier, Duan, Xia, Zhao, Fumin, Liu, Xinghui, Wang, Xiaodong, Peng, Bing
• Format: Article
• Language: English
• Subjects: Bladder; Bleeding; Cervix; Cesarean Section; Confidence intervals; Derivation; Female; Field strength; Hemoglobin; Hemorrhage; Humans; Indicators; Magnetic Resonance Imaging; Placenta; placenta accreta; placenta previa; Placenta Previa - diagnostic imaging; Placenta Previa - surgery; Postpartum Hemorrhage - diagnostic imaging; Postpartum Hemorrhage - surgery; Pregnancy; Pregnancy complications; Regression analysis; Retrospective Studies; risk factors; scoring system; Statistical analysis; Statistical tests; Uterus
• ISSN: 1053-1807; 1522-2586
• DOI: 10.1002/jmri.26922

Background Placenta previa and accreta are serious obstetric conditions that are associated with a high risk of intraoperative massive hemorrhage. Purpose To develop a scoring system for intraoperative massive hemorrhage combining MRI and clinical characteristics to predict the risk of massive hemorrhage in placenta previa and accreta Study Type Retrospective cohort study. Subjects In all, 374 patients consisting of 259 patients with placenta previa and accreta after previous cesarean section (CS) for the derivation cohort and 115 patients for the validation cohort. Field Strength/Sequence 1.5T single‐shot fast spin‐echo sequence. [Correction added on October 23, 2019, after first online publication: The field strength in the preceding sentence was corrected.] Assessment Using the derivation cohort, clinical and MRI data were collected and multivariable logistic regressions analysis was conducted to develop a scoring system for prediction of intraoperative massive bleeding (blood loss volume > 2000 mL). Finally, the scoring system was validated on 115 patients. Statistical Tests Student's t‐test, Mann–Whitney U‐test, X 2 statistics, multivariable analysis, and receiver operating characteristic (ROC) analysis. Results Ten indicators, including clinically maternal age (1 point), preoperative hemoglobin level (1 point), gravidity number (1 point), number of CS (1 point), and MRI T2 dark intraplacental bands (4 points), cervical canal length (3 points), placenta thickness on the uterine scar area (4 points), empty vascular shadow of the uterus (1 point), low signal discontinuity in the muscular layer of the posterior wall of the bladder (6 points) and attachment position of the placenta (1 point) were imputed. From the ROC analysis, a total score of 7 points was identified as the optimal cutoff value, allowing good differentiation of intraoperative massive bleeding in the derivation cohort (AUC, 0.863; 95% confidence interval [CI]: 0.811–0.916) and in the validation cohort (AUC, 0.933; 95% CI: 0.885–0.980). Data Conclusion The scoring system for intraoperative massive hemorrhage consists of MRI and clinical indicators, and using a cutoff value of 7 points for a high risk of massive bleeding, the developed scoring system could accurately assess the risk of intraoperative massive hemorrhage in patients with placenta previa and accreta. This scoring system can potentially reduce the incidence of intraoperative massive bleeding by identifying patients at high risk