Maternal vascular malformation in the placenta is an indicator for fetal growth restriction irrespective of neonatal birthweight

To study the association between placental pathology and neonatal birthweight and outcomes, and whether a combination of first trimester biomarkers and fetal growth velocity can predict placental lesions. The presence of maternal vascular malperfusion (MVM) lesions (Amsterdam criteria) was recorded...

Full description

Saved in:
Bibliographic Details
Published in:Placenta (Eastbourne) 2019-11, Vol.87, p.8-15
Main Authors: Hendrix, M.L.E., Bons, J.A.P., Alers, N.O., Severens-Rijvers, C.A.H., Spaanderman, M.E.A., Al-Nasiry, S.
Format: Article
Language:English
Subjects:
Birth weight centile
Fetal growth restriction
Maternal vascular malperfusion
Placenta pathology
Ultrasound
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To study the association between placental pathology and neonatal birthweight and outcomes, and whether a combination of first trimester biomarkers and fetal growth velocity can predict placental lesions. The presence of maternal vascular malperfusion (MVM) lesions (Amsterdam criteria) was recorded in a retrospective cohort of singleton pregnancies in the Maastricht University Medical Centre, 2011–2018. First trimester maternal characteristics and PAPP-A, PlGF and sFlt-1 levels were collected. Fetal growth velocities were calculated (mm/week) from 20 to 32 weeks for abdominal circumference, biparietal diameter, head circumference and femur length. Data were compared between neonates with ‘small for gestational age’ (SGA  p50 (reference), using one-way ANOVA and post hoc test. There were significantly more MVM lesions in the SGA group (94.6% p 
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2019.09.003