Magneto is ineffective in controlling electrical properties of cerebellar Purkinje cells

It was recently reported that a magnetic actuator, Magneto, can control neuronal firings at magnetic strength as low as 50 mT (ref. 1 ), offering an exciting non-invasive approach to manipulating neuronal activity in a variety of research and clinical applications. We investigated whether Magneto ca...

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Bibliographic Details
Published in:Nature neuroscience 2020-09, Vol.23 (9), p.1041-1043
Main Authors: Xu, Fang-Xiao, Zhou, Lin, Wang, Xin-Tai, Jia, Fan, Ma, Kuang-Yi, Wang, Na, Lin, Li, Xu, Fu-Qiang, Shen, Ying
Format: Article
Language:English
Subjects:
13/1
13/51
631/378/1697
631/378/87
64/60
9/74
Actuators
Animal Genetics and Genomics
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Cerebellum
Electric properties
Electrical properties
Electrophysiology
Emotional behavior
Health aspects
Magnetic fields
Magnetic Phenomena
Magnetic properties
Matters Arising
Motor skill learning
Neurobiology
Neurosciences
Physiological aspects
Purkinje Cells
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Summary:It was recently reported that a magnetic actuator, Magneto, can control neuronal firings at magnetic strength as low as 50 mT (ref. 1 ), offering an exciting non-invasive approach to manipulating neuronal activity in a variety of research and clinical applications. We investigated whether Magneto can be used to manipulate electric properties of Purkinje cells in the cerebellum, which play critical roles in motor learning and emotional behaviors 2 . Surprisingly, we found that the application of a magnetic field did not change any electrical properties of Purkinje cells expressing Magneto, raising serious doubt about the previous claim that Magneto can readily be used as a magnetic actuator 1 .
ISSN:1097-6256
1546-1726
DOI:10.1038/s41593-019-0475-3