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Assessment of neuron-specific enolase, S100B and malondialdehyde levels in serum and vitreous of patients with proliferative diabetic retinopathy
Purpose To assess the vitreous and serum levels of neuron-specific enolase (NSE), S100B and malondialdehyde (MDA) in proliferative diabetic retinopathy (PDR) cases and investigate the correlation between preoperative and postoperative anatomical and clinical features. Materials and methods The study...
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| Published in: | International ophthalmology 2020, Vol.40 (1), p.227-234 |
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| container_title | International ophthalmology |
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| creator | Asadova, Vusala Gul, Zulfiye Buyukuysal, Rifat Levent Yalcinbayir, Ozgur |
| description | Purpose
To assess the vitreous and serum levels of neuron-specific enolase (NSE), S100B and malondialdehyde (MDA) in proliferative diabetic retinopathy (PDR) cases and investigate the correlation between preoperative and postoperative anatomical and clinical features.
Materials and methods
The study group included patients who had pars plana vitrectomy (PPV) for PDR. The control group included non-diabetic individuals who underwent PPV surgery for vitreoretinal interface disorders. Samples of serum were taken from all participants preoperatively, while vitreous samples were taken during the PPV. Vitreous and serum levels of NSE, S100B and MDA were measured, and comparisons were made between the groups.
Results
The study group consisted of 56 eyes of 56 cases with PDR. The control group consisted of 20 eyes of 20 cases. The concentrations of vitreous NSE, S100B and MDA were significantly higher than the control group (
p
|
| doi_str_mv | 10.1007/s10792-019-01175-9 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2299767917</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2299767917</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-578fcb537529f913c37f664203f662c47582d9ec02f10e419434738ea23c3f13</originalsourceid><addsrcrecordid>eNp9kU2PEzEMhiMEYsvCH-CAInHhwEA-ZibNcVnxJa3Egb1H6YxDs8okJZ4p6s_gH-O2C0gcOCS2nMevHb2MPZfijRTCvEUpjFWNkJaONF1jH7CV7IxuVK_FQ7YSsu-azgh5wZ4g3gkhrLH9Y3ahiZLCqhX7eYUIiBPkmZfAMyy15AZ3MMQQBw65JI_wmn-lie-4zyOffCp5jD6NsD2MwBPsISGPmSPUZTox-zhXKAseJXd-jqSO_Eect3xXS4oBKhX3wElmAzPNqXTnQuj28JQ9Cj4hPLuPl-z2w_vb60_NzZePn6-vbppBm26mb63DsOkoVzZYqaka-r5VQlNQQ2u6tRotDEIFKaCVttWt0WvwitAg9SV7dZaljb4vgLObIg6Qks_HzZ1S1preWGkIffkPeleWmmm5E6VVp1pNlDpTQy2IFYLb1Tj5enBSuKNf7uyXI7_cyS9nqenFvfSymWD80_LbIAL0GUB6yt-g_p39H9lfuSehbw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2299325243</pqid></control><display><type>article</type><title>Assessment of neuron-specific enolase, S100B and malondialdehyde levels in serum and vitreous of patients with proliferative diabetic retinopathy</title><source>Springer Nature</source><creator>Asadova, Vusala ; Gul, Zulfiye ; Buyukuysal, Rifat Levent ; Yalcinbayir, Ozgur</creator><creatorcontrib>Asadova, Vusala ; Gul, Zulfiye ; Buyukuysal, Rifat Levent ; Yalcinbayir, Ozgur</creatorcontrib><description>Purpose
To assess the vitreous and serum levels of neuron-specific enolase (NSE), S100B and malondialdehyde (MDA) in proliferative diabetic retinopathy (PDR) cases and investigate the correlation between preoperative and postoperative anatomical and clinical features.
Materials and methods
The study group included patients who had pars plana vitrectomy (PPV) for PDR. The control group included non-diabetic individuals who underwent PPV surgery for vitreoretinal interface disorders. Samples of serum were taken from all participants preoperatively, while vitreous samples were taken during the PPV. Vitreous and serum levels of NSE, S100B and MDA were measured, and comparisons were made between the groups.
Results
The study group consisted of 56 eyes of 56 cases with PDR. The control group consisted of 20 eyes of 20 cases. The concentrations of vitreous NSE, S100B and MDA were significantly higher than the control group (
p
< 0.0001,
p
< 0.05,
p
< 0.001, respectively). Serum levels were statistically different for NSE and S100B (
p
< 0.05).
Conclusion
Our results clearly show that vitreous levels of S100B, NSE and MDA and serum concentrations of NSE and S100B increased significantly in patients with PDR. The findings may possibly indicate neurodegeneration and oxidative stress; therefore, these markers may have a diagnostic value in patients with PDR.</description><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-019-01175-9</identifier><identifier>PMID: 31571092</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers - blood ; Diabetes ; Diabetes mellitus ; Diabetic retinopathy ; Diabetic Retinopathy - diagnosis ; Diabetic Retinopathy - metabolism ; Diabetic Retinopathy - surgery ; Diagnostic systems ; Female ; Follow-Up Studies ; Humans ; Male ; Malondialdehyde ; Malondialdehyde - metabolism ; Medicine ; Medicine & Public Health ; Middle Aged ; Neurodegeneration ; Ophthalmology ; Original Paper ; Oxidative Stress ; Patients ; Phosphopyruvate hydratase ; Phosphopyruvate Hydratase - metabolism ; Prognosis ; Prospective Studies ; Retina - pathology ; Retinopathy ; S100 Calcium Binding Protein beta Subunit - metabolism ; S100b protein ; Serum levels ; Statistical methods ; Surgery ; Tomography, Optical Coherence ; Vitrectomy ; Vitreous Body - metabolism ; Young Adult</subject><ispartof>International ophthalmology, 2020, Vol.40 (1), p.227-234</ispartof><rights>Springer Nature B.V. 2019</rights><rights>International Ophthalmology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-578fcb537529f913c37f664203f662c47582d9ec02f10e419434738ea23c3f13</citedby><cites>FETCH-LOGICAL-c375t-578fcb537529f913c37f664203f662c47582d9ec02f10e419434738ea23c3f13</cites><orcidid>0000-0002-8872-0074</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31571092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Asadova, Vusala</creatorcontrib><creatorcontrib>Gul, Zulfiye</creatorcontrib><creatorcontrib>Buyukuysal, Rifat Levent</creatorcontrib><creatorcontrib>Yalcinbayir, Ozgur</creatorcontrib><title>Assessment of neuron-specific enolase, S100B and malondialdehyde levels in serum and vitreous of patients with proliferative diabetic retinopathy</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose
To assess the vitreous and serum levels of neuron-specific enolase (NSE), S100B and malondialdehyde (MDA) in proliferative diabetic retinopathy (PDR) cases and investigate the correlation between preoperative and postoperative anatomical and clinical features.
Materials and methods
The study group included patients who had pars plana vitrectomy (PPV) for PDR. The control group included non-diabetic individuals who underwent PPV surgery for vitreoretinal interface disorders. Samples of serum were taken from all participants preoperatively, while vitreous samples were taken during the PPV. Vitreous and serum levels of NSE, S100B and MDA were measured, and comparisons were made between the groups.
Results
The study group consisted of 56 eyes of 56 cases with PDR. The control group consisted of 20 eyes of 20 cases. The concentrations of vitreous NSE, S100B and MDA were significantly higher than the control group (
p
< 0.0001,
p
< 0.05,
p
< 0.001, respectively). Serum levels were statistically different for NSE and S100B (
p
< 0.05).
Conclusion
Our results clearly show that vitreous levels of S100B, NSE and MDA and serum concentrations of NSE and S100B increased significantly in patients with PDR. The findings may possibly indicate neurodegeneration and oxidative stress; therefore, these markers may have a diagnostic value in patients with PDR.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers - blood</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetic retinopathy</subject><subject>Diabetic Retinopathy - diagnosis</subject><subject>Diabetic Retinopathy - metabolism</subject><subject>Diabetic Retinopathy - surgery</subject><subject>Diagnostic systems</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Malondialdehyde</subject><subject>Malondialdehyde - metabolism</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neurodegeneration</subject><subject>Ophthalmology</subject><subject>Original Paper</subject><subject>Oxidative Stress</subject><subject>Patients</subject><subject>Phosphopyruvate hydratase</subject><subject>Phosphopyruvate Hydratase - metabolism</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Retina - pathology</subject><subject>Retinopathy</subject><subject>S100 Calcium Binding Protein beta Subunit - metabolism</subject><subject>S100b protein</subject><subject>Serum levels</subject><subject>Statistical methods</subject><subject>Surgery</subject><subject>Tomography, Optical Coherence</subject><subject>Vitrectomy</subject><subject>Vitreous Body - metabolism</subject><subject>Young Adult</subject><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU2PEzEMhiMEYsvCH-CAInHhwEA-ZibNcVnxJa3Egb1H6YxDs8okJZ4p6s_gH-O2C0gcOCS2nMevHb2MPZfijRTCvEUpjFWNkJaONF1jH7CV7IxuVK_FQ7YSsu-azgh5wZ4g3gkhrLH9Y3ahiZLCqhX7eYUIiBPkmZfAMyy15AZ3MMQQBw65JI_wmn-lie-4zyOffCp5jD6NsD2MwBPsISGPmSPUZTox-zhXKAseJXd-jqSO_Eect3xXS4oBKhX3wElmAzPNqXTnQuj28JQ9Cj4hPLuPl-z2w_vb60_NzZePn6-vbppBm26mb63DsOkoVzZYqaka-r5VQlNQQ2u6tRotDEIFKaCVttWt0WvwitAg9SV7dZaljb4vgLObIg6Qks_HzZ1S1preWGkIffkPeleWmmm5E6VVp1pNlDpTQy2IFYLb1Tj5enBSuKNf7uyXI7_cyS9nqenFvfSymWD80_LbIAL0GUB6yt-g_p39H9lfuSehbw</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Asadova, Vusala</creator><creator>Gul, Zulfiye</creator><creator>Buyukuysal, Rifat Levent</creator><creator>Yalcinbayir, Ozgur</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8872-0074</orcidid></search><sort><creationdate>2020</creationdate><title>Assessment of neuron-specific enolase, S100B and malondialdehyde levels in serum and vitreous of patients with proliferative diabetic retinopathy</title><author>Asadova, Vusala ; Gul, Zulfiye ; Buyukuysal, Rifat Levent ; Yalcinbayir, Ozgur</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-578fcb537529f913c37f664203f662c47582d9ec02f10e419434738ea23c3f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers - blood</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetic retinopathy</topic><topic>Diabetic Retinopathy - diagnosis</topic><topic>Diabetic Retinopathy - metabolism</topic><topic>Diabetic Retinopathy - surgery</topic><topic>Diagnostic systems</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>Malondialdehyde - metabolism</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neurodegeneration</topic><topic>Ophthalmology</topic><topic>Original Paper</topic><topic>Oxidative Stress</topic><topic>Patients</topic><topic>Phosphopyruvate hydratase</topic><topic>Phosphopyruvate Hydratase - metabolism</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Retina - pathology</topic><topic>Retinopathy</topic><topic>S100 Calcium Binding Protein beta Subunit - metabolism</topic><topic>S100b protein</topic><topic>Serum levels</topic><topic>Statistical methods</topic><topic>Surgery</topic><topic>Tomography, Optical Coherence</topic><topic>Vitrectomy</topic><topic>Vitreous Body - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asadova, Vusala</creatorcontrib><creatorcontrib>Gul, Zulfiye</creatorcontrib><creatorcontrib>Buyukuysal, Rifat Levent</creatorcontrib><creatorcontrib>Yalcinbayir, Ozgur</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Databases</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asadova, Vusala</au><au>Gul, Zulfiye</au><au>Buyukuysal, Rifat Levent</au><au>Yalcinbayir, Ozgur</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of neuron-specific enolase, S100B and malondialdehyde levels in serum and vitreous of patients with proliferative diabetic retinopathy</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><addtitle>Int Ophthalmol</addtitle><date>2020</date><risdate>2020</risdate><volume>40</volume><issue>1</issue><spage>227</spage><epage>234</epage><pages>227-234</pages><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Purpose
To assess the vitreous and serum levels of neuron-specific enolase (NSE), S100B and malondialdehyde (MDA) in proliferative diabetic retinopathy (PDR) cases and investigate the correlation between preoperative and postoperative anatomical and clinical features.
Materials and methods
The study group included patients who had pars plana vitrectomy (PPV) for PDR. The control group included non-diabetic individuals who underwent PPV surgery for vitreoretinal interface disorders. Samples of serum were taken from all participants preoperatively, while vitreous samples were taken during the PPV. Vitreous and serum levels of NSE, S100B and MDA were measured, and comparisons were made between the groups.
Results
The study group consisted of 56 eyes of 56 cases with PDR. The control group consisted of 20 eyes of 20 cases. The concentrations of vitreous NSE, S100B and MDA were significantly higher than the control group (
p
< 0.0001,
p
< 0.05,
p
< 0.001, respectively). Serum levels were statistically different for NSE and S100B (
p
< 0.05).
Conclusion
Our results clearly show that vitreous levels of S100B, NSE and MDA and serum concentrations of NSE and S100B increased significantly in patients with PDR. The findings may possibly indicate neurodegeneration and oxidative stress; therefore, these markers may have a diagnostic value in patients with PDR.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>31571092</pmid><doi>10.1007/s10792-019-01175-9</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8872-0074</orcidid></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biomarkers - blood Diabetes Diabetes mellitus Diabetic retinopathy Diabetic Retinopathy - diagnosis Diabetic Retinopathy - metabolism Diabetic Retinopathy - surgery Diagnostic systems Female Follow-Up Studies Humans Male Malondialdehyde Malondialdehyde - metabolism Medicine Medicine & Public Health Middle Aged Neurodegeneration Ophthalmology Original Paper Oxidative Stress Patients Phosphopyruvate hydratase Phosphopyruvate Hydratase - metabolism Prognosis Prospective Studies Retina - pathology Retinopathy S100 Calcium Binding Protein beta Subunit - metabolism S100b protein Serum levels Statistical methods Surgery Tomography, Optical Coherence Vitrectomy Vitreous Body - metabolism Young Adult |
| title | Assessment of neuron-specific enolase, S100B and malondialdehyde levels in serum and vitreous of patients with proliferative diabetic retinopathy |
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