What is the Mechanism of Nitric Oxide Conversion into Nitrosonium Ions Ensuring S-Nitrosating Processes in Living Organisms

Here, I present the data testifying that the conversion of free radical NO molecules to nitrosonium ions (NO + ), which are necessary for the realization of one of NO biological effects (S-nitrosation), may occur in living organisms after binding NO molecules to loosely bound iron (Fe 2+ ions) with...

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Bibliographic Details
Published in:Cell biochemistry and biophysics 2019-12, Vol.77 (4), p.279-292
Main Author: Vanin, Anatoly F.
Format: Article
Language:English
Subjects:
Autocrine signalling
Biochemistry
Biological and Medical Physics
Biological effects
Biomedical and Life Sciences
Biophysics
Biotechnology
Cell Biology
Conversion
Coordination compounds
Disproportionation
Free radicals
Ions
Iron
Life Sciences
Ligands
Nitric oxide
Nitrosation
Organisms
Oxidation
Paracrine signalling
Pharmacology/Toxicology
Regulators
Review Paper
Thiols
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Summary:Here, I present the data testifying that the conversion of free radical NO molecules to nitrosonium ions (NO + ), which are necessary for the realization of one of NO biological effects (S-nitrosation), may occur in living organisms after binding NO molecules to loosely bound iron (Fe 2+ ions) with the subsequent mutual one-electron oxidation–reduction of NO molecules (their disproportionation). Inclusion of thiol-containing substances as iron ligands into this process prevents hydrolysis of NO + ions bound to iron thus providing the formation of stable dinitrosyl iron complexes (DNIC) with thiol ligands. Such complexes act in living organisms as donors of NO and NO + , providing stabilization and transfer of these agents via the autocrine and paracrine pathways. Without loosely bound iron (labile iron pool) and thiols participating in the DNIC formation, NO functioning as one of universal regulators of diverse metabolic processes would be impossible.
ISSN:1085-9195
1559-0283
DOI:10.1007/s12013-019-00886-1