Serum lipid profiles of young Japanese women with iron deficiency without anemia

• Published in: Journal of trace elements in medicine and biology 2020-01, Vol.57, p.126408-126408, Article 126408
• Main Authors: Sawada, Takako, Konomi, Aki, Yokoi, Katsuhiko
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Anemia, Iron-Deficiency - blood; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Cornell Medical Index (CMI) health questionnaire; Female; High-density lipoprotein cholesterol (HDL-C); Humans; Iron - blood; Iron deficiency without anemia; Lipid profile; Lipids - blood; Serum ferritin (sFer); Surveys and Questionnaires; Triglycerides - blood; Women around twenty years old; Young Adult
• ISSN: 0946-672X; 1878-3252
• DOI: 10.1016/j.jtemb.2019.126408

We aimed to evaluate the association between iron deficiency without anemia (IDNA) and serum lipid profiles in young women of around 20 years of age. This study included non-anemic (hemoglobin ≥ 12 g/dL) female volunteers aged 18 to 22 years who were not taking mineral/vitamin supplements and living in the metropolitan area of Tokyo, Japan. These volunteers were classified into two groups based on their sFer (serum ferritin) levels: normal group (sFer ≥ 20 ng/mL, n = 36) and IDNA group (sFer < 20 ng/mL, n = 29). Venous blood samples were obtained from the antecubital veins of these volunteers after 10–12-h fasting to measure the hematological and biochemical parameters, including lipid levels and iron status. The results of each group were compared using Student’s t-test or the Mann–Whitney U test (for inhomogeneous variance). The serum cholesterol levels varied depending on the iron status in the women. Serum high-density lipoprotein cholesterol (HDL-C) levels in the IDNA group were significantly higher (P = 0.006) than that in the normal group. However, the levels of total cholesterol (T-CHO), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) were not significantly different between the groups. Serum LDL-C levels were positively and significantly correlated with sFer levels in the IDNA group (Kendall’s rank correlation 0.264, P = 0.044), but not in the normal group. The sFer level was not correlated with serum HDL-C in both groups. The reason for the high serum HDL-C levels in young women with IDNA is not yet clear. Compared to the normal group, the frequency of eating bread containing bran was significantly higher (P = 0.031) and that for yogurt was significantly lower (P = 0.040) in the IDNA group. The proportion of the women who were susceptible to infection, which was measured using the Cornell Medical Index, was significantly higher in the IDNA group than in the normal group. Among those susceptible to infection, the serum HDL-C level of the volunteers in the IDNA group was significantly higher than that of the volunteers in the normal group (P = 0.024). Our findings suggest that lipid parameters may be associated with IDNA and susceptibility to infection. Further research is needed to elucidate the mechanisms underlying the changes in the serum cholesterol levels in individuals with IDNA and the clinical significance of these findings.