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Psychiatric disorders are a common prognostic marker for worse outcome in patients with idiopathic intracranial hypertension

•Psychiatric disorders are sevenfold more common in IIH patients compared to general population.•The IIH patients with pre-existing psychiatric diagnosis had more often empty sella at diagnosis.•The IIH patients with a pre-existing psychiatric diagnosis have worse subjective outcome. Idiopathic intr...

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Published in:Clinical neurology and neurosurgery 2019-11, Vol.186, p.105527-105527, Article 105527
Main Authors: Puustinen, Tero, Tervonen, Joona, Avellan, Cecilia, Jyrkkänen, Henna-Kaisa, Paterno, Jussi J., Hartikainen, Päivi, Vanhanen, Ulla, Leinonen, Ville, Lehto, Soili M., Elomaa, Antti-Pekka, Huttunen, Terhi J.
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creator Puustinen, Tero
Tervonen, Joona
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Leinonen, Ville
Lehto, Soili M.
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description •Psychiatric disorders are sevenfold more common in IIH patients compared to general population.•The IIH patients with pre-existing psychiatric diagnosis had more often empty sella at diagnosis.•The IIH patients with a pre-existing psychiatric diagnosis have worse subjective outcome. Idiopathic intracranial hypertension (IIH) is aetiologically unknown disorder that associates with endocrinological disturbances, including dysfunction of hypothalamic-pituitary-adrenal-axis. Neuroendocrinological dysfunctions have also been characterized in psychiatric disorders, and therefore we investigated the presence of psychiatric disorders of patients with IIH in a well-defined cohort. A total of 51 patients with IIH were included. Patient demographics, symptoms, imaging data, ophthalmological and clinical findings were collected. At the time of diagnosis the mean age was 32.5years (SD 10.7), the body mass index was 37.1 kg/m2 (SD 7.4), and the opening pressure 29.1 mmHg (SD 6.2). A total of 88.2% of patients were female and 45.1% were diagnosed with a psychiatric co-morbidity prior to IIH diagnosis. The mean follow-up time was 4.4 years (SD 5.4). The overall treatment outcome was significantly poorer on a group of patients with psychiatric diagnosis when compared to individuals without such history (p = 0.001), but there were no differences in the resolution of papilledema (p = 0.405). Patients with IIH and psychiatric disorders had more often empty sella on their imaging at diagnosis when compared to patients without psychiatric co-morbidity (p = 0.044). Psychiatric disorders are highly prevalent in patients with IIH and associate with worse subjective outcomes. These findings advocate for monitoring the mental health of patients with IIH and warrant further multidisciplinary research to understand the potentially underlying psychosocial and neuroendocrinological mechanisms.
doi_str_mv 10.1016/j.clineuro.2019.105527
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Idiopathic intracranial hypertension (IIH) is aetiologically unknown disorder that associates with endocrinological disturbances, including dysfunction of hypothalamic-pituitary-adrenal-axis. Neuroendocrinological dysfunctions have also been characterized in psychiatric disorders, and therefore we investigated the presence of psychiatric disorders of patients with IIH in a well-defined cohort. A total of 51 patients with IIH were included. Patient demographics, symptoms, imaging data, ophthalmological and clinical findings were collected. At the time of diagnosis the mean age was 32.5years (SD 10.7), the body mass index was 37.1 kg/m2 (SD 7.4), and the opening pressure 29.1 mmHg (SD 6.2). A total of 88.2% of patients were female and 45.1% were diagnosed with a psychiatric co-morbidity prior to IIH diagnosis. The mean follow-up time was 4.4 years (SD 5.4). The overall treatment outcome was significantly poorer on a group of patients with psychiatric diagnosis when compared to individuals without such history (p = 0.001), but there were no differences in the resolution of papilledema (p = 0.405). Patients with IIH and psychiatric disorders had more often empty sella on their imaging at diagnosis when compared to patients without psychiatric co-morbidity (p = 0.044). Psychiatric disorders are highly prevalent in patients with IIH and associate with worse subjective outcomes. These findings advocate for monitoring the mental health of patients with IIH and warrant further multidisciplinary research to understand the potentially underlying psychosocial and neuroendocrinological mechanisms.</description><identifier>ISSN: 0303-8467</identifier><identifier>EISSN: 1872-6968</identifier><identifier>DOI: 10.1016/j.clineuro.2019.105527</identifier><identifier>PMID: 31586855</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Age ; Anxiety ; Body mass ; Body mass index ; Clinical outcomes ; Demographics ; Demography ; Diagnosis ; Family medical history ; Gastrointestinal surgery ; Headaches ; Hypertension ; Hypothalamic-pituitary-adrenal axis ; Hypothalamic-pituitary-adrenal-axis (HPA-axis) ; Hypothalamus ; Idiopathic intracranial hypertension (IIH) ; Intracranial pressure (ICP) ; Major depressive disorder (MDD) ; Mental disorders ; Morbidity ; Multidisciplinary research ; Neurology ; NMR ; Nuclear magnetic resonance ; Optic nerve ; Patients ; Pituitary ; Psychiatric disorders ; Schizophrenia ; Swelling ; Tinnitus</subject><ispartof>Clinical neurology and neurosurgery, 2019-11, Vol.186, p.105527-105527, Article 105527</ispartof><rights>2019 The Authors</rights><rights>Copyright © 2019 The Authors. 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The overall treatment outcome was significantly poorer on a group of patients with psychiatric diagnosis when compared to individuals without such history (p = 0.001), but there were no differences in the resolution of papilledema (p = 0.405). Patients with IIH and psychiatric disorders had more often empty sella on their imaging at diagnosis when compared to patients without psychiatric co-morbidity (p = 0.044). Psychiatric disorders are highly prevalent in patients with IIH and associate with worse subjective outcomes. 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Idiopathic intracranial hypertension (IIH) is aetiologically unknown disorder that associates with endocrinological disturbances, including dysfunction of hypothalamic-pituitary-adrenal-axis. Neuroendocrinological dysfunctions have also been characterized in psychiatric disorders, and therefore we investigated the presence of psychiatric disorders of patients with IIH in a well-defined cohort. A total of 51 patients with IIH were included. Patient demographics, symptoms, imaging data, ophthalmological and clinical findings were collected. At the time of diagnosis the mean age was 32.5years (SD 10.7), the body mass index was 37.1 kg/m2 (SD 7.4), and the opening pressure 29.1 mmHg (SD 6.2). A total of 88.2% of patients were female and 45.1% were diagnosed with a psychiatric co-morbidity prior to IIH diagnosis. The mean follow-up time was 4.4 years (SD 5.4). The overall treatment outcome was significantly poorer on a group of patients with psychiatric diagnosis when compared to individuals without such history (p = 0.001), but there were no differences in the resolution of papilledema (p = 0.405). Patients with IIH and psychiatric disorders had more often empty sella on their imaging at diagnosis when compared to patients without psychiatric co-morbidity (p = 0.044). Psychiatric disorders are highly prevalent in patients with IIH and associate with worse subjective outcomes. These findings advocate for monitoring the mental health of patients with IIH and warrant further multidisciplinary research to understand the potentially underlying psychosocial and neuroendocrinological mechanisms.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>31586855</pmid><doi>10.1016/j.clineuro.2019.105527</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-4282-4687</orcidid><orcidid>https://orcid.org/0000-0002-5442-4314</orcidid><oa>free_for_read</oa></addata></record>
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ispartof Clinical neurology and neurosurgery, 2019-11, Vol.186, p.105527-105527, Article 105527
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subjects Age
Anxiety
Body mass
Body mass index
Clinical outcomes
Demographics
Demography
Diagnosis
Family medical history
Gastrointestinal surgery
Headaches
Hypertension
Hypothalamic-pituitary-adrenal axis
Hypothalamic-pituitary-adrenal-axis (HPA-axis)
Hypothalamus
Idiopathic intracranial hypertension (IIH)
Intracranial pressure (ICP)
Major depressive disorder (MDD)
Mental disorders
Morbidity
Multidisciplinary research
Neurology
NMR
Nuclear magnetic resonance
Optic nerve
Patients
Pituitary
Psychiatric disorders
Schizophrenia
Swelling
Tinnitus
title Psychiatric disorders are a common prognostic marker for worse outcome in patients with idiopathic intracranial hypertension
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