PI3K–AKT Signaling Activation and Icariin: The Potential Effects on the Perimenopausal Depression-Like Rat Model

Icariin is a prenylated flavonol glycoside isolated from Epimedium herb, and has been shown to be its main bioactive component. Recently, the antidepressant-like mechanism of icariin has been increasingly evaluated and demonstrated. However, there are few studies that have focused on the involvement...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2019-10, Vol.24 (20), p.3700
Main Authors: Cao, Li-Hua, Qiao, Jing-Yi, Huang, Hui-Yuan, Fang, Xiao-Yan, Zhang, Rui, Miao, Ming-San, Li, Xiu-Min
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Behavior, Animal
Biomarkers
Brain research
Cell growth
Depression - etiology
Depression - metabolism
Depression - psychology
Disease Models, Animal
Drug dosages
Female
Flavonoids - pharmacology
forced swimming test
Hormone replacement therapy
icariin
Mental depression
open field test
Ovary - metabolism
perimenopausal depression
Perimenopause - psychology
Phosphatidylinositol 3-Kinases - metabolism
pi3k–akt signaling
Proto-Oncogene Proteins c-akt - metabolism
Rats
Receptors, Estrogen - metabolism
Signal Transduction - drug effects
Spleen
Studies
Womens health
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