In vitro activity of hybrid lavender essential oils against multidrug resistant strains of Pseudomonas aeruginosa

Introduction: Lavender is an evergreen shrub native to Northern Africa and other mountainous Mediterranean regions. It grows throughout Southern Europe, the United States, and Australia. Lavender essential oil has been used since ancient times and is known for its anti-inflammatory, antidepressant,...

Full description

Saved in:
Bibliographic Details
Published in:Journal of infection in developing countries 2018-01, Vol.12 (1), p.9-14
Main Authors: Donadu, Matthew, Usai, Donatella, Pinna, Antonio, Porcu, Tiziana, Mazzarello, Vittorio, Fiamma, Maura, Marchetti, Mauro, Cannas, Sara, Delogu, Giovanni, Zanetti, Stefania, Molicotti, Paola
Format: Article
Language:English
Subjects:
Antifungal agents
Antimicrobial agents
Cytotoxicity
Multidrug resistant organisms
Oils & fats
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction: Lavender is an evergreen shrub native to Northern Africa and other mountainous Mediterranean regions. It grows throughout Southern Europe, the United States, and Australia. Lavender essential oil has been used since ancient times and is known for its anti-inflammatory, antidepressant, antiseptic, antifungal and antimicrobial properties. Methodology: in this study, the antimicrobial activity of two Lavender essential oils (Lavanda sumian and Lavanda grosso) against 16 multidrug-resistant P. aeruginosa strains from clinical ocular samples taken from migrant patients has been investigated. The in vitro cytotoxic activity on human Wong-Kilbourne derivative (WKD) conjunctiva cells from healthy patients and nitric oxide synthase (NOS) activity on murine macrophage (J774.1A) were also evaluated. Results: L. sumian showed lower antimicrobial activity when compared to L. grosso. Both lavender oils tested had no cytotoxic effect at very low concentrations, mostly L. grosso. The essential oils extracted from L. sumian and L. grosso significantly reduced NOS in a cell model. Conclusion: Increase in drug resistance and lack of new antibiotics may encourage the development of natural antimicrobial treatments.
ISSN:1972-2680
2036-6590
1972-2680
DOI:10.3855/jidc.9920