Development, characterisation and nasal deposition of melatonin-loaded pectin/hypromellose microspheres

In this study, we present the development of spray-dried pectin/hypromellose microspheres as efficient melatonin carrier for targeted nasal delivery. Different pectin to hypromellose weight ratios in the spray-dried feed were employed (i.e. 1:0, 3:1, 1:1 and 1:3) in order to optimise microsphere phy...

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Bibliographic Details
Published in:European journal of pharmaceutical sciences 2020-01, Vol.141, p.105115-105115, Article 105115
Main Authors: Nižić, Laura, Potaś, Joanna, Winnicka, Katarzyna, Szekalska, Marta, Erak, Iva, Gretić, Matija, Jug, Mario, Hafner, Anita
Format: Article
Language:English
Subjects:
Adhesiveness
Administration, Intranasal
Drug Liberation
Hypromellose
Hypromellose Derivatives - administration & dosage
Hypromellose Derivatives - chemistry
Melatonin
Melatonin - administration & dosage
Melatonin - chemistry
Microspheres
Models, Biological
Nasal deposition
Nasal Mucosa - chemistry
Nasal Mucosa - metabolism
Pectin
Pectins - administration & dosage
Pectins - chemistry
Spray-drying
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Summary:In this study, we present the development of spray-dried pectin/hypromellose microspheres as efficient melatonin carrier for targeted nasal delivery. Different pectin to hypromellose weight ratios in the spray-dried feed were employed (i.e. 1:0, 3:1, 1:1 and 1:3) in order to optimise microsphere physicochemical properties influencing overall powder behaviour prior, during and upon nasal delivery. All microspheres assured complete melatonin entrapment and increased dissolution rate in relation to pure melatonin powder. Among all combinations tested, combining pectin with hypromellose at 1:3 wt ratio resulted in the microspheres with the highest potential for melatonin nasal delivery as they assured highest swelling ability and most prominent mucoadhesive properties. Studies on deposition profile revealed adequate turbinate and olfactory deposition of microsphere/lactose monohydrate powder blend administered nasally using MIAT® device, complementing findings relevant for their therapeutic potential. In conclusion, developed microspheres bear the potential to ensure prolonged melatonin retention at the nasal mucosa, improved bioavailability and advanced therapeutic outcome. [Display omitted]
ISSN:0928-0987
1879-0720
DOI:10.1016/j.ejps.2019.105115