Insight into an outbreak of Salmonella Choleraesuis var. Kunzendorf in wild boars

•S. Choleraesuis from wild boars, domestic pigs and human, was characterized.•Results suggest a different origin of wild boars isolates compared to pig isolates.•Phylogenetic relationship was found between the human and the wild boars isolates. An unusual mortality of wild boars occurred in Italy fr...

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Published in:Veterinary microbiology 2019-11, Vol.238, p.108423-108423, Article 108423
Main Authors: Longo, Alessandra, Losasso, Carmen, Vitulano, Federica, Mastrorilli, Eleonora, Turchetto, Sara, Petrin, Sara, Mantovani, Claudio, Dalla Pozza, Maria Cristina, Ramon, Elena, Conedera, Gabriella, Citterio, Carlo V., Ricci, Antonia, Barco, Lisa, Lettini, Antonia Anna
Format: Article
Language:English
Subjects:
Animals
Bacterial genomics
Disease Outbreaks - veterinary
Epidemics
Hogs
Infection diseases
Infections
Invasiveness
Outbreak investigation
Outbreaks
Phylogeny
Salmonella
Salmonella - physiology
Salmonella Infections, Animal - epidemiology
Sus scrofa
Sus scrofa - microbiology
Swine
Whole genome sequencing
Wild boars
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Summary:•S. Choleraesuis from wild boars, domestic pigs and human, was characterized.•Results suggest a different origin of wild boars isolates compared to pig isolates.•Phylogenetic relationship was found between the human and the wild boars isolates. An unusual mortality of wild boars occurred in Italy from 2012 to 2015 due to Salmonella Choleraesuis infection. In order to confirm the occurrence of an outbreak of S. Choleraesuis in wild boars and to epidemically characterise the unique S. Choleraesuis biovar, a collection of isolates belonging to wild boars was investigated from the phenotypic, molecular and genomic points of view (PFGE and WGS). Moreover, the possibility of transmission to domestic pigs and humans, temporally and geographically close to the wild boar epidemic, was tested by also including in the panel isolates from infected domestic pigs and from one human case of infection. Wild boar isolates displayed a high genetic correlation, thus suggesting they are part of the same outbreak, with a common invasiveness potential. Conversely, no correlation between pig isolates and those from the other sources (wild boars and human) was found. However, the phylogenetic and PFGE analyses suggest a high degree of similarity between the human and the investigated wild boar outbreak isolates, implying the potential for the spread of Salmonella Choleraesuis among these species.
ISSN:0378-1135
1873-2542
DOI:10.1016/j.vetmic.2019.108423