Predictors of unfavourable outcome in aneurysmal subarachnoid haemorrhage

• Published in: Neurologia i neurochirurgia polska 2019-01, Vol.53 (6), p.421-427
• Main Authors: Nastasovic, Tijana, Milakovic, Branko, Stosic, Mila, Eric Marinkovic, Jelena, Ilic, Rosanda, Milicevic, Mihailo, Cvrkota, Irena, Radinovic, Kristina, Petrovic, Olga, Grujicic, Danica
• Format: Article
• Language: English
• Subjects: Adult; Anesthesiology; Aneurysms; Biomarkers; Blood pressure; Cardiovascular disease; Catheters; Disability; Edema; Electrocardiography; Female; Heart rate; Hemorrhage; Humans; Hydrocephalus; Hypertension; Intracranial Aneurysm; Intracranial pressure; Male; Medical imaging; Middle Aged; Mortality; Neurosurgery; Patients; Prospective Studies; Pulmonary arteries; Subarachnoid Hemorrhage; X-rays
• ISSN: 0028-3843; 1897-4260
• DOI: 10.5603/PJNNS.A2019.0051

Mortality rates following aneurysmal subarachnoid haemorrhage (aSAH) have decreased due to improvements in diagnoses and the management of complications, as well as early obliteration of the aneurysms. Neurogenic pulmonary oedema (NPO) is a clinical syndrome associated with an acute increase in intracranial pressure and a release of catecholamines into the circulation. This study investigated independent predictors of unfavourable outcomes (Glasgow Outcome Scores 1, 2 or 3) in patients with aSAH. A total of 262 patients with aSAH (162 females) were included in this prospective study. Clinical characteristics were assessed, and electrocardiographic, serum cardiac and inflammatory biomarker measurements were recorded on admission. Outcomes were assessed three months after admission. Univariate and multivariate analyses of these data were used to predict unfavourable outcomes. A total of 156 patients (59.54%) had unfavourable outcomes. Compared to those who had favourable outcomes, patients with unfavourable outcomes were significantly older (54.37 ± 10.56 vs. 49.13 ± 10.77 years; p < 0.001) and had more severe aSAHs (Hunt and Hess grades ≥ 3: 82.7% vs. 39.6%; p < 0.001). Patients with unfavourable outcomes were more likely to have NPO (10.3% vs. 2.8%; p = 0.023), hydrocephalus (34.0% vs. 20.8%; p = 0.02), and aneurysm reruptures (28.2% vs. 3.8%; p < 0.001). Independent predictors of an unfavourable outcome included Hunt and Hess grades ≥ 3 (odds ratio [OR], 4.291; 95% confidence interval [CI], 2.168-8.491; p < 0.001), increased systolic blood pressure on admission (OR, 1.020; 95% CI, 1.002-1.038; p = 0.03), increased heart rate (HR) on admission (OR, 1.024; 95% CI, 1.001-1.048; p = 0.04), and aneurysm rerupture (OR, 4.961; 95% CI, 1.461-16.845; p = 0.01). These findings suggest that aneurysm reruptures, as well as increased blood pressure and HR, are associated with unfavourable outcomes in patients with aSAH.