Impact of multipoint pacing on projected battery longevity in cardiac resynchronization therapy. An IRON‐MPP study sub‐analysis

Background Multipoint pacing (MPP) may improve clinical outcomes in patients with cardiac resynchronization therapy defibrillators (CRT‐D), but its impact on battery longevity in a real‐world population has not been investigated in large trials. Objective Compare projected battery longevity in CRT‐D...

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Published in:Journal of cardiovascular electrophysiology 2019-12, Vol.30 (12), p.2885-2891
Main Authors: Forleo, Giovanni B., Gasperetti, Alessio, Ricciardi, Danilo, Curnis, Antonio, Bertaglia, Emanuele, Calò, Leonardo, Pignalberi, Carlo, Calzolari, Vittorio, Ribatti, Valentina, Lavalle, Carlo, Potenza, Domenico, Tondi, Lara, Natale, Veronica, Notarstefano, Pasquale, Viecca, Maurizio, Morani, Giovanni, Biffi, Mauro, Giammaria, Massimo, Zanon, Francesco, Santini, Luca
Format: Article
Language:English
Subjects:
battery longevity
cardiac resynchronization therapy
Clinical trials
Deactivation
Defibrillators
Heart
heart failure
implantable cardioverter‐defibrillator
Implantation
Iron
Longevity
multipoint pacing
Ventricle
World population
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Summary:Background Multipoint pacing (MPP) may improve clinical outcomes in patients with cardiac resynchronization therapy defibrillators (CRT‐D), but its impact on battery longevity in a real‐world population has not been investigated in large trials. Objective Compare projected battery longevity in CRT‐D patients with and without MPP during long‐term follow‐up. Methods The Italian registry on multipoint left ventricular pacing (IRON‐MPP) is a prospective, multicenter registry of patients implanted with MPP‐capable CRT‐D devices. Projected battery longevity during follow‐up was compared for patients with MPP (MPP ON) vs single‐site (MPP OFF) left ventricular pacing at CRT‐D implantation. A sub‐analysis excluded crossover patients with MPP activation or deactivation occurring after implantation. A second sub‐analysis excluded patients with a right or left ventricular pacing amplitude >2.5 V. Results Out of 237 CRT‐D patients (71 ± 9 years, 81% male) followed for 1.9 ± 0.8 years, 102 (43%) had MPP ON at implantation. Programmed atrial and ventricular outputs and percentage of pacing were similar between groups. MPP was associated with a 0.44 years reduction in projected battery longevity (P = .03) during long‐term follow‐up. Results were similar for the first and second sub‐analyses, with a 0.57 years (P 
ISSN:1045-3873
1540-8167
DOI:10.1111/jce.14254