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Increased risk of osteoporosis in patients with peptic ulcer: a follow-up study using a national sample cohort

Summary We performed a nationwide, population-based cohort study to investigate the risk of osteoporosis in patients with peptic ulcer disease in South Korea and concluded that peptic ulcer disease is associated with an increased risk of osteoporosis. Purpose This study aimed to evaluate the associa...

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Published in:Archives of osteoporosis 2019-10, Vol.14 (1), p.105-105, Article 105
Main Authors: Choi, Hyo Geun, Rhim, Chae Chun, Yoon, Ji Young, Park, Bum Jung, Min, Chan Yang, Lee, Suk Woo
Format: Article
Language:English
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Summary:Summary We performed a nationwide, population-based cohort study to investigate the risk of osteoporosis in patients with peptic ulcer disease in South Korea and concluded that peptic ulcer disease is associated with an increased risk of osteoporosis. Purpose This study aimed to evaluate the association between peptic ulcer disease (PUD) and the occurrence of osteoporosis using a national sample cohort from South Korea. Methods Using the national cohort study from the Korean National Health Insurance Service, we extracted data for patients with PUD ( n = 50,002) and for 1:1 matched control participants ( n = 50,002); we then analyzed the occurrence of osteoporosis from 2002 to 2013. The patients were matched according to age, sex, income, region of residence, and past medical history. A stratified Cox proportional hazards model was used to analyze the hazard ratios (HRs) and the 95% confidence intervals (CIs). Subgroup analyses were performed based on age and sex. Results The adjusted HR for osteoporosis was 1.36 (95% CI = 1.33–1.40, P < 0.001) in the PUD group. In the subgroup analysis based on age and sex, the respective adjusted HRs of PUD for osteoporosis were 1.33 (95% CI = 1.21–1.47) in the < 65-year-old group of men and 1.42 (95% CI = 1.30–1.56) in the ≥ 65-year-old group of men (each P < 0.001). The respective adjusted HRs of PUD for osteoporosis were 1.34 (95% CI = 1.29–1.39) in the < 65-year-old group of women and 1.38 (95% CI = 1.33–1.47) in the ≥ 65-year-old group of women (each P < 0.001). Conclusion In the current nationwide cohort study, we found that PUD is associated with an increased risk of osteoporosis regardless of sex.
ISSN:1862-3522
1862-3514
DOI:10.1007/s11657-019-0659-1