Targeting PTSD

In a sham-controlled study by N.S. Philip et al, the efficacy of intermittent theta-burst stimulation (iTBS) targeted at the right dorsolateral prefrontal cortex applied over a 10-day initial treatment period was assessed in veterans with posttraumatic stress disorder (PTSD). The study results suppo...

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Bibliographic Details
Published in:The American journal of psychiatry 2019-11, Vol.176 (11), p.894-896
Main Authors: McDonald, William M, van Rooij, Sanne J.H
Format: Article
Language:English
Subjects:
Humans
Medical imaging
Medical treatment
Neurophysiology
Post traumatic stress disorder
Prefrontal Cortex
Stress Disorders, Post-Traumatic
Transcranial Magnetic Stimulation
Treatment Outcome
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Summary:In a sham-controlled study by N.S. Philip et al, the efficacy of intermittent theta-burst stimulation (iTBS) targeted at the right dorsolateral prefrontal cortex applied over a 10-day initial treatment period was assessed in veterans with posttraumatic stress disorder (PTSD). The study results support this innovative approach for the treatment of PTSD and demonstrate both the safety and efficacy of iTBS and the use of neuroimaging biomarkers to develop therapeutic treatment targets. Here, McDonald and van Rooij discuss the value of iTBS and places the findings from this study in the context of other TMS studies. They conclude that the study outlines the importance of emerging neuromodulation therapies and neuroimaging in providing personalized treatments and understanding the neurophysiology of psychiatric disorders. Neuroanatomic pathways can be mapped to determine the most appropriate stimulation sites. Subcortical targets that are particularly important in the neurophysiology of PTSD can be identified and targeted with iTBS, and Philip et al demonstrate the potential for targeted treatment in PTSD.
ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.2019.19080895