Free triiodothyronine (fT3) and B-type natriuretic peptide (BNP) predict in-hospital mortality after valve surgery

Background Increased B-type natriuretic peptide (BNP) and decreased free triiodothyronine (fT3) are associated with increased mortality after cardiac surgery. However, previous studies have addressed mortality primarily in patients undergoing coronary artery bypass graft, and not in those undergoing...

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Published in:General thoracic and cardiovascular surgery 2020-06, Vol.68 (6), p.585-595
Main Authors: Mukaida, Hiroshi, Hayashida, Masakazu, Matsushita, Satoshi, Endo, Daisuke, Oishi, Atsumi, Shimada, Akie, Hata, Hiroaki, Kajimoto, Kan, Yamamoto, Taira, Amano, Atsushi
Format: Article
Language:English
Subjects:
Biomarkers
Blood
Cardiac Surgery
Cardiology
Demography
Ejection fraction
Fentanyl
Heart failure
Heart surgery
Hemoglobin
Kinases
Medicine
Medicine & Public Health
Mortality
Original Article
Peptides
Regression analysis
Surgical Oncology
Thoracic Surgery
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Summary:Background Increased B-type natriuretic peptide (BNP) and decreased free triiodothyronine (fT3) are associated with increased mortality after cardiac surgery. However, previous studies have addressed mortality primarily in patients undergoing coronary artery bypass graft, and not in those undergoing valve surgery. We assessed abilities of BNP and fT3 to predict mortality after valve surgery. Methods This retrospective study included 1050 consecutive patients who underwent valve surgery with normothermic cardiopulmonary bypass (CPB). Predictors of in-hospital mortality were identified with logistic regression analyses. Cutoff values were determined with receiver operating curve analyses. Results There were 23 deaths (2.2%). By univariate analyses, fT3, log-transformed BNP (log BNP), cholinesterase, estimated glomerular filtration rate, and albumin were profoundly associated with in-hospital mortality ( p  
ISSN:1863-6705
1863-6713
DOI:10.1007/s11748-019-01244-x