Serum creatinine to cystatin C ratio predicts skeletal muscle mass and strength in patients with non-dialysis chronic kidney disease

Muscle wasting is highly prevalent in patients with chronic kidney disease (CKD). However, the assessment of skeletal muscle mass and strength in clinical settings is not commonly available. We aimed to evaluate the feasibility of serum creatinine/cystatin C (Cr/CysC) ratio in the assessment of musc...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2020-08, Vol.39 (8), p.2435-2441
Main Authors: Lin, Yu-Li, Chen, Shu-Yuan, Lai, Yu-Hsien, Wang, Chih-Hsien, Kuo, Chiu-Huang, Liou, Hung-Hsiang, Hsu, Bang-Gee
Format: Article
Language:English
Subjects:
Chronic kidney disease
Creatinine
Cystatin C
Muscle wasting
Sarcopenia
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Summary:Muscle wasting is highly prevalent in patients with chronic kidney disease (CKD). However, the assessment of skeletal muscle mass and strength in clinical settings is not commonly available. We aimed to evaluate the feasibility of serum creatinine/cystatin C (Cr/CysC) ratio in the assessment of muscle wasting. In 272 patients with CKD aged 66.5 ± 15.1 years, skeletal muscle mass and handgrip strength (HGS) were assessed. Skeletal muscle index (SMI) was calculated as skeletal muscle mass/height2. Low muscle mass was defined as SMI below the sex-specific 10th percentile of study population and low handgrip strength as less than 26 Kg for men and 18 Kg for women. The Cr/CysC ratio was significantly lower in both the low SMI and low HGS groups. Moreover, the Cr/CysC ratio correlated with SMI (r = .306, p 
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2019.10.027