DNA-Compatible Diazo-Transfer Reaction in Aqueous Media Suitable for DNA-Encoded Chemical Library Synthesis

DNA-encoded chemical libraries (DECLs) are increasingly employed in hit discovery toward proteins of pharmaceutical interest. Protected amino acids are the most commonly used building blocks for the construction of DECLs; therefore, the expansion of reaction scope with the subsequent free amine is h...

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Bibliographic Details
Published in:Organic letters 2019-12, Vol.21 (23), p.9555-9558
Main Authors: Gironda-Martínez, Adrián, Neri, Dario, Samain, Florent, Donckele, Etienne J
Format: Article
Language:English
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Summary:DNA-encoded chemical libraries (DECLs) are increasingly employed in hit discovery toward proteins of pharmaceutical interest. Protected amino acids are the most commonly used building blocks for the construction of DECLs; therefore, the expansion of reaction scope with the subsequent free amine is highly desired. Here, we developed a robust DNA-compatible diazo-transfer reaction using imidazole-1-sulfonyl azide tetrafluoroborate salt converting a wide range of primary amines into their corresponding azides in good to excellent yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b03726