Association of circulating selenium concentration with dyslipidemia: Results from the NHANES

• Published in: Journal of trace elements in medicine and biology 2020-03, Vol.58, p.126438-126438, Article 126438
• Main Authors: Huang, Yu-qing, Shen, Geng, Lo, Kenneth, Huang, Jia-yi, Liu, Lin, Chen, Chao-lei, Yu, Yu-ling, Sun, Shuo, Zhang, Bin, Feng, Ying-qing
• Format: Article
• Language: English
• Subjects: Atherogenic index; Dyslipidemia; Lipid profiles; NHANES; Non-high-density lipoprotein cholesterol; Selenium
• ISSN: 0946-672X; 1878-3252
• DOI: 10.1016/j.jtemb.2019.126438

•Circulating selenium was obviously associated with lipid parameters including TC, TG, LDL-C, HDL-C, non-HDL-C and AI.•Circulating selenium concentrations were an independent risk for dyslipidemia.•There was a nonlinear association of circulating selenium with TC, HDL-C, LDL-C, AI and non-HDL-C. Observational studies have suggested that selenium levels might associate with the risk of cardio-metabolic diseases, but how circulating selenium is related to dyslipidemia remains inconclusive. To investigate the association of circulating selenium levels with lipid profiles and dyslipidemia among US adults. Using the data collected from the National Health and Nutrition Examination Survey (NHANES 1999–2006), we performed multivariate logistic regression to examine the association of circulating selenium levels (in quartiles) with total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-HDL-C, and atherogenic index (AI). We included 2903 adults (49.3 % male) (average age: 61.9) for analysis. Circulating selenium had non-linear association with TC, LDL-C, HDL-C, and AI (all p 147.00 μg/L) had the higher odds of elevated TG (OR: 1.75, 95% CI = 1.14, 2.68), TC (OR: 2.47, 95% CI = 1.62, 3.76), LDL-C (OR: 2.52, 95% CI = 1.60, 3.96), non-HDL-C (OR: 2.17, 95% CI = 1.41, 3.33), AI (OR: 1.20, 95% CI = 0.73, 1.97) and low-HDL-C (OR: 2.10, 95% CI = 1.19, 3.72). Similar patterns were observed in subgroup analysis. Higher circulating selenium levels had non-linear association with lipid profiles and the increased odds of dyslipidemia.