The effects of clinical decision support systems on insulin use: A systematic review

• Published in: Journal of evaluation in clinical practice 2020-08, Vol.26 (4), p.1292-1301
• Main Authors: Jia, Pengli, Jia, Pengyan, Chen, JingJing, Zhao, Pujing, Zhang, Mingming
• Format: Article
• Language: English
• Subjects: CDSS; clinical decision support systems; Decision support systems; Drug administration; Glucose; Glucose monitoring; Insulin; insulin use
• ISSN: 1356-1294; 1365-2753
• DOI: 10.1111/jep.13291

Background A clinical decision support system (CDSS) is a computerized system using case‐based reasoning to assist clinicians in assessing disease status, in selecting appropriate therapy or in making other clinical decisions. Previous randomized controlled trials (RCTs or trials) have shown that CDSSs have the potential to improve the insulin use, but the evidence was conflicting and uncertain. The purpose of our study was to determine whether a CDSS improves the use of insulin. Method PubMed, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched from their inception to October 2018. The quality assessment was based on the risk of bias criteria of the Cochrane Handbook. Results Twenty‐four RCTs, involving 7653 participants, were included. Thirteen of those trials (54.2%) used a computerized algorithm or a computer‐assisted insulin protocol for insulin dose and therapy adjustment, of which 30.8% (four of 13) found significant changes. Of 10 trials that measured mean blood glucose levels and the 11 trials reported HbA1c, the computerized insulin dose adjustment resulted in lower mean blood glucose levels in 70.0% (seven of 10) and 36.4% (four of 11) of RCTs, respectively. Additionally, a significant reduction of hyperglycaemia events was reported in three of six RCTs. The evidence in a majority of the 24 RCTs was of moderate quality. Conclusions CDSSs have the potential to improve the insulin use and blood glucose control in a clinical setting. The methodologies in these studies were of mixed quality. Better designed and longer‐term studies are required to ensure a larger and more reliable evidence base on the effects of CDSS intervention on insulin use.