Low free T3 to free T4 ratio was associated with low muscle mass and impaired physical performance in community-dwelling aged population

Summary In aged population, the association of thyroid hormones on physical performance, especially within their normal range, has yet to be elucidated. In this study, individuals with low serum free T3/free T4 were likely to have low muscle mass and impaired physical performance. Purpose We aimed t...

Full description

Saved in:
Bibliographic Details
Published in:Osteoporosis international 2020-03, Vol.31 (3), p.525-531
Main Authors: Kong, S. H., Kim, J. H., Park, Y. J., Lee, J. H., Hong, A. R., Shin, C. S., Cho, N. H.
Format: Article
Language:English
Subjects:
Aged
Cohort Studies
Endocrinology
Female
Hand Strength
Humans
Independent Living
Male
Medicine
Medicine & Public Health
Middle Aged
Muscle, Skeletal
Muscles
Original Article
Orthopedics
Physical Functional Performance
Population
Post-menopause
Rheumatology
Skeletal muscle
Thyroid gland
Thyroid hormones
Thyroxine
Triiodothyronine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary In aged population, the association of thyroid hormones on physical performance, especially within their normal range, has yet to be elucidated. In this study, individuals with low serum free T3/free T4 were likely to have low muscle mass and impaired physical performance. Purpose We aimed to evaluate the associations of muscle mass, strength, and physical performance with thyroid hormone in an aged euthyroid population from a community-based cohort. Methods We examined 918 men aged over 60 years and 1215 postmenopausal women from the Ansung cohort study. Appendicular skeletal muscle mass divided by square of height (ASM/ht 2 ) was used as the muscle mass index. Hand grip strength was measured using a hydraulic dynamometer. Physical performance was assessed using the short physical performance battery (SPPB). Results Participants with higher tertiles of free T3 and free T3/free T4 were younger and had higher ASM/ht 2 , stronger hand grip strength, and higher SPPB scores than those in the lower tertiles. In adjusted models, men within higher tertiles of free T3 had higher ASM/ht 2 compared with those within lower tertiles ( p  = 0.033), whereas subjects with higher tertiles of free T4 had lower ASM/ht 2 compared with those within lower tertiles ( p  = 0.043). Subjects within higher tertiles of free T3/free T4 had higher ASM/ht 2 ( p  
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-019-05137-w