Unfavourable treatment outcomes in tuberculosis patients with different vitamin D status and blood glucose levels in a programme setting in China

Objective Tuberculosis (TB) treatment success rates are high in China, but there are still a considerable number of cases who have unfavourable treatment outcomes (UTO). We aimed to determine the proportion of TB patients with UTO and to assess whether baseline characteristics that included glycaemi...

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Bibliographic Details
Published in:Tropical medicine & international health 2020-03, Vol.25 (3), p.373-379
Main Authors: Lin, Yan, Bai, Yunlong, Zhang, Tiejuan, Kang, Wanli, Kang, Demei, Miao, Qiang, Wang, Yunlong, Shao, Hongshan, Li, Xiangwen, Brigden, Grania, Dlodlo, Riitta A., Harries, Anthony D.
Format: Article
Language:English
Subjects:
Blood
Blood glucose
Calciferol
China
Chine
Clinical outcomes
Data analysis
Diabetes mellitus
Glucose
glucose sanguin
Hyperglycemia
Patients
Regression analysis
résultat de traitement
treatment outcome
tuberculose
Tuberculosis
Vitamin D
Vitamin deficiency
vitamine D
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Summary:Objective Tuberculosis (TB) treatment success rates are high in China, but there are still a considerable number of cases who have unfavourable treatment outcomes (UTO). We aimed to determine the proportion of TB patients with UTO and to assess whether baseline characteristics that included glycaemic status [normal fasting blood glucose (FBG), transient hyperglycaemia and diabetes mellitus (DM)] and vitamin D status were associated with UTO. Method Prospective cohort study conducted between November 2015 and July 2016 at six clinics within routine TB services in Jilin province, where persons with TB were consecutively recruited. Data analysis was performed using the chi‐squared test and multivariate logistic regression. Results Of the 306 recruited TB patients, 96 (31.4%) had smear‐positive pulmonary TB, 187 (61.1%) had smear‐negative pulmonary TB and 23 (7.5%) had extrapulmonary TB (EPTB). Of these, 95 (31.1%) had normal blood glucose, 83 (27.1%) had transient hyperglycaemia and 128 (41.8%) had DM. 227 (74.2%) patients had vitamin D deficiency/severe deficiency. There were 125 (40.8%) patients with UTO of whom the majority were lost to follow‐up (57.6%) or not evaluated (28.8%). UTO was significantly associated with smear‐negative pulmonary TB (P = 0.009), EPTB (P 
ISSN:1360-2276
1365-3156
DOI:10.1111/tmi.13355