Concomitant systemic lupus erythematosus might have a negative impact on the biochemical responses to treatment in patients with primary biliary cholangitis

Background Primary biliary cholangitis (PBC) is often overlapping with other autoimmune conditions, including systemic lupus erythematosus (SLE). Since the concomitant PBC and SLE are rare, the impacts of SLE on the response and prognosis in ursodeoxycholic acid (UDCA)–treated patients with PBC rema...

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Bibliographic Details
Published in:Clinical rheumatology 2020-03, Vol.39 (3), p.795-803
Main Authors: Fan, Xiaoli, Men, Ruoting, Ni, Ping, Lu, Changli, Si, Tengfei, Ma, Yun, Yang, Li
Format: Article
Language:English
Subjects:
Adult
Aged
Alanine
Alanine transaminase
Alkaline phosphatase
Alkaline Phosphatase - blood
Aspartate aminotransferase
Bilirubin
Bilirubin - blood
Biochemical characteristics
China
Cholangitis
Disease Progression
Female
Hemoglobin
Humans
Kaplan-Meier Estimate
Liver Cirrhosis, Biliary - complications
Liver Cirrhosis, Biliary - drug therapy
Liver Cirrhosis, Biliary - pathology
Lupus
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - pathology
Male
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Original Article
Patients
Platelets
Prognosis
Retrospective Studies
Rheumatology
Systemic lupus erythematosus
Ursodeoxycholic acid
Ursodeoxycholic Acid - therapeutic use
Young Adult
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Summary:Background Primary biliary cholangitis (PBC) is often overlapping with other autoimmune conditions, including systemic lupus erythematosus (SLE). Since the concomitant PBC and SLE are rare, the impacts of SLE on the response and prognosis in ursodeoxycholic acid (UDCA)–treated patients with PBC remain unclear. Methods A PBC database of 769 patients at West China hospital was used to identify 26 patients with concomitant PBC and SLE. The clinical and biochemical characteristics of these patients were collected and analyzed. Propensity score matching was used to compensate for the differences in age, total bilirubin, and alkaline phosphatase. The biochemical responses and prognoses were compared between the patients with and without concomitant SLE. Results The female-to-male ratio was 25:1 in the PBC patients with concomitant SLE. Compared with the group with PBC alone, the median hemoglobin and albumin values in the PBC-SLE group at the time of diagnosis of PBC were lower (both P  
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-019-04853-2