Choroidal structural changes in preterm children with and without retinopathy of prematurity

• Published in: Acta ophthalmologica (Oxford, England) England), 2020-08, Vol.98 (5), p.e611-e616
• Main Authors: Lavric, Alenka, Tekavcic Pompe, Manca, Markelj, Spela, Ding, Jianbin, Mahajan, Sarakshi, Khandelwal, Neha, Agrawal, Rupesh
• Format: Article
• Language: English
• Subjects: Acuity; Birth weight; Children; choroidal thickness; choroidal vascularity index; Demography; Eye; Gestational age; optical coherence tomography; Premature birth; preterm children; Retinopathy; retinopathy of prematurity
• ISSN: 1755-375X; 1755-3768
• DOI: 10.1111/aos.14324

Purpose Evaluate choroidal structural changes in preterm children with and without retinopathy of prematurity (ROP) using image binarization technique on swept‐source optical coherence tomography (SS‐OCT) scans. Methods Prospective case–control study. Forty‐one (79 eyes) children aged 5–15 years with a history of preterm birth and 33 (63 eyes) age‐matched full‐term children were recruited. Demographics including gestational age at birth, birth weight and history of ROP were documented. All subjects had undergone complete eye examinations, including best‐corrected visual acuity and SS‐OCT imaging. Subfoveal choroidal thickness (SFCT) was calculated, and images were binarized to obtain stromal and luminal areas (LA). The choroidal vascularity index (CVI) was derived from the proportion of LA to the total subfoveal choroidal area. Results There were no significant differences in SFCT between the preterm children with (286.63 ± 83.98 μm) or without (306.59 ± 77.29 μm) ROP and the full‐term children (311.82 ± 42.87; p = 0.20 and 0.67, respectively). The CVI was significantly reduced in the preterm children with ROP (68.66 ± 3.24%; p = 0.005) compared with the CVI in the full‐term control group (71.37 ± 3.63%); however, the CVI in the preterm children without ROP (71.68 ± 3.09%; p = 0.93) was not significantly affected. Conclusion The reduced CVI in preterm children with ROP may indicate compromised choroidal vascularity. The CVI was found to be a more sensitive OCT biomarker than the SFCT and may be helpful in evaluating associated choroidal structural changes in preterm children, especially those with a history of ROP.