miRNA deregulation in childhood acute lymphoblastic leukemia: a systematic review

Despite remarkable improvements in survival of childhood acute lymphoblastic leukemia (ALL), nonresponding or relapsing patients still represent one of the most frequent causes of death by disease in children. Accurate patient risk stratification based on genetic markers could increases survival rat...

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Bibliographic Details
Published in:Epigenomics 2020-01, Vol.12 (1), p.69-80
Main Authors: Gutierrez-Camino, Angela, Garcia-Obregon, Susana, Lopez-Lopez, Elixabet, Astigarraga, Itziar, Garcia-Orad, Africa
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
Biomarkers
Childhood
childhood acute lymphoblastic leukemia
Children
Chromosomes
Classification
Deregulation
diagnosis
Diagnostic systems
Gene expression
Genetic markers
Leukemia
Lymphatic leukemia
Medical prognosis
MicroRNAs
miRNA
Pediatrics
prognosis
signature
Studies
subtype classification
Survival
Systematic review
treatment response
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Summary:Despite remarkable improvements in survival of childhood acute lymphoblastic leukemia (ALL), nonresponding or relapsing patients still represent one of the most frequent causes of death by disease in children. Accurate patient risk stratification based on genetic markers could increases survival rates. miRNAs can represent novel candidates with diagnostic, predictive and prognostic potential; however, many groups investigated their involvement with contradictory results. To clarify the role of miRNAs as biomarkers through a systematic review. From a revision of 45 manuscripts, we found that miR-128 and miR-181 overexpression could represent markers for ALL diagnosis and underexpression of miR-708 and miR-99a could be markers for bad prognosis. These signatures could refine classification and risk stratification of patients and improve ALL outcome.
ISSN:1750-1911
1750-192X
DOI:10.2217/epi-2019-0154