Therapeutic “Tool” in Reconstruction and Regeneration of Tissue Engineering for Osteochondral Repair

• Published in: Applied biochemistry and biotechnology 2020-06, Vol.191 (2), p.785-809
• Main Authors: Hu, Xueyan, Xu, Jie, Li, Wenfang, Li, Liying, Parungao, Roxanne, Wang, Yiwei, Zheng, Shuangshuang, Nie, Yi, Liu, Tianqing, Song, Kedong
• Format: Article
• Language: English
• Subjects: Animals; Biochemistry; Biomedical materials; Bioreactors; Biotechnology; Bone and Bones; Bone marrow; Bone Marrow Cells; Bone Transplantation; Cartilage; Cartilage, Articular; Cell Differentiation; Cell Proliferation; Chemistry; Chemistry and Materials Science; Chondrogenesis; Defects; Differentiation (biology); Humans; Mesenchymal Stem Cells; Monolayers; Multilayers; Osteogenesis; Recovery of function; Regeneration; Regeneration (physiology); Regenerative medicine; Repair; Scaffolds; Stem Cells; Subchondral bone; Tissue engineering; Tissue Engineering - methods; Tissue Scaffolds; Umbilical cord
• ISSN: 0273-2289; 1559-0291
• DOI: 10.1007/s12010-019-03214-8

Repairing osteochondral defects to restore joint function is a major challenge in regenerative medicine. However, with recent advances in tissue engineering, the development of potential treatments is promising. In recent years, in addition to single-layer scaffolds, double-layer or multilayer scaffolds have been prepared to mimic the structure of articular cartilage and subchondral bone for osteochondral repair. Although there are a range of different cells such as umbilical cord stem cells, bone marrow mesenchyml stem cell, and others that can be used, the availability, ease of preparation, and the osteogenic and chondrogenic capacity of these cells are important factors that will influence its selection for tissue engineering. Furthermore, appropriate cell proliferation and differentiation of these cells is also key for the optimal repair of osteochondral defects. The development of bioreactors has enhanced methods to stimulate the proliferation and differentiation of cells. In this review, we summarize the recent advances in tissue engineering, including the development of layered scaffolds, cells, and bioreactors that have changed the approach towards the development of novel treatments for osteochondral repair.