Renal dysfunction as intrahospital prognostic indicator in acute pulmonary embolism

Acute pulmonary embolism (PE), due to hemodynamic disturbances, may lead to multi-organ damage, including acute renal dysfunction. The aim of our study was to investigate the predictive role of renal dysfunction at admission regarding the short-term mortality and bleeding risk in hospitalized PE pat...

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Bibliographic Details
Published in:International journal of cardiology 2020-03, Vol.302, p.143-149
Main Authors: Salinger-Martinovic, Sonja, Dimitrijevic, Zorica, Stanojevic, Dragana, Momčilović, Stefan, Kostic, Tomislav, Koracevic, Goran, Subotic, Bojana, Dzudovic, Boris, Stefanovic, Branislav, Matijasevic, Jovan, Miric, Milica, Markovic-Nikolic, Natasa, Nikolic, Maja, Miloradovic, Vladimir, Kos, Ljiljana, Kovacevic-Preradovic, Tamara, Srdanovic, Ilija, Stanojevic, Jelena, Obradovic, Slobodan
Format: Article
Language:English
Subjects:
Acute Disease
Aged
Bleeding
Cause of Death - trends
Female
Follow-Up Studies
Glomerular Filtration Rate - physiology
Humans
Kidney Diseases - etiology
Kidney Diseases - physiopathology
Male
Middle Aged
Prognosis
Pulmonary embolism
Pulmonary Embolism - complications
Pulmonary Embolism - mortality
Pulmonary Embolism - physiopathology
Renal dysfunction
Retrospective Studies
Risk Assessment
Serbia - epidemiology
Survival Rate - trends
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Summary:Acute pulmonary embolism (PE), due to hemodynamic disturbances, may lead to multi-organ damage, including acute renal dysfunction. The aim of our study was to investigate the predictive role of renal dysfunction at admission regarding the short-term mortality and bleeding risk in hospitalized PE patients. The retrospective cohort study included 1330 consecutive patients with PE. The glomerular filtration rate (GFR) was calculated using the serum creatinine value and Cocroft-Gault formula, at hospital admission. Primary outcomes were all-cause mortality and PE-related mortality in the 30 days following admission, as well as major bleeding events. Based on the estimated GFR, patients were divided into three groups: the first with GFR  60 mL/min. A multivariable analysis showed that GFR at admission was strongly associated with all-cause death, as well as with death due to PE. Patients in the first and second group had a significantly higher risk of 30-day all-cause mortality (HR 7.109, 95% CI 4.243–11.911, p 
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2019.12.025