Feasibility Study of a Novel Protease-Activated Fluorescent Imaging System for Real-Time, Intraoperative Detection of Residual Breast Cancer in Breast Conserving Surgery

Background Obtaining tumor-free margins is critical to prevent recurrence after lumpectomy for breast cancer. Unfortunately, current approaches leave positive margins that require second surgeries in 20–40% of patients. We assessed the LUM Imaging System for real-time, intraoperative detection of re...

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Bibliographic Details
Published in:	Annals of surgical oncology 2020-06, Vol.27 (6), p.1854-1861
Main Authors:	Smith, Barbara L., Lanahan, Conor R., Specht, Michelle C., Kelly, Bridget N., Brown, Carson, Strasfeld, David B., Ferrer, Jorge M., Rai, Upahvan, Tang, Rong, Rice-Stitt, Travis, Biernacka, Anna, Brachtel, Elena F., Gadd, Michele A.
Format:	Article
Language:	English
Subjects:	Adult Aged Breast Neoplasms - pathology Breast Neoplasms - surgery Breast Oncology Carcinoma, Ductal, Breast - pathology Carcinoma, Ductal, Breast - surgery Carcinoma, Lobular - pathology Carcinoma, Lobular - surgery Diagnostic Imaging Feasibility Studies Female Fluorescent Dyes - chemistry Follow-Up Studies Humans Intraoperative Care Mastectomy, Segmental - methods Medicine Medicine & Public Health Middle Aged Neoplasm Invasiveness Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - surgery Neoplasm, Residual - diagnosis Neoplasm, Residual - surgery Oncology Peptide Hydrolases - metabolism Prognosis Retrospective Studies Surgery Surgical Oncology
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