Men are from mars, women are from venus: Factors responsible for gender differences in outcomes after surgical and trans-catheter aortic valve replacement

Females suffer higher operative (30-day) mortality than males after surgical aortic valve replacement (SAVR). In contrast, outcomes after trans-catheter aortic valve replacement (TAVR) seem to favor females, both in terms of procedural mortality, and more prominently, medium to long-term survival. W...

Full description

Saved in:
Bibliographic Details
Published in:Trends in cardiovascular medicine 2021-01, Vol.31 (1), p.34-46
Main Authors: Goel, Harsh, Kumar, Ashish, Garg, Nadish, Mills, James D.
Format: Article
Language:English
Subjects:
Age
Aortic stenosis
Aortic valve
Aortic Valve - physiopathology
Aortic Valve - surgery
Aortic Valve Stenosis - mortality
Aortic Valve Stenosis - physiopathology
Aortic Valve Stenosis - surgery
Catheters
Chronic obstructive pulmonary disease
Clinical Decision-Making
FDA approval
Female
Females
Gender
Gender differences
Health Status Disparities
Heart failure
Heart Valve Prosthesis Implantation - adverse effects
Heart Valve Prosthesis Implantation - mortality
Humans
Male
Morbidity
Mortality
Outcomes
Population
Postoperative Complications - mortality
Prostheses
Recovery of Function
Risk Assessment
Risk Factors
Sex Characteristics
Sex differences
Sex Factors
Suffering
Surgical aortic valve replacement
Trans-catheter aortic valve replacement
Transcatheter Aortic Valve Replacement - adverse effects
Transcatheter Aortic Valve Replacement - mortality
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Females suffer higher operative (30-day) mortality than males after surgical aortic valve replacement (SAVR). In contrast, outcomes after trans-catheter aortic valve replacement (TAVR) seem to favor females, both in terms of procedural mortality, and more prominently, medium to long-term survival. With an ever-greater number of TAVR procedures being performed, an understanding of factors responsible for gender differences in outcomes after the two AVR modalities is critical for better patient selection. Current evidence suggests that this gender difference in outcomes after SAVR and TAVR stems from differences in baseline risk profiles, as well as inherent anatomic/physiological differences between genders. This review attempts to examine these clinical and physiological factors, with a goal of guiding better patient selection for each AVR modality, and to highlight areas that beg further investigation.
ISSN:1050-1738
1873-2615
DOI:10.1016/j.tcm.2019.11.010