Differences in cardiac geometry in relation to body size among neonates with abnormal prenatal growth and body size at birth

• Published in: Ultrasound in obstetrics & gynecology 2020-12, Vol.56 (6), p.864-871
• Main Authors: Olander, R. F. W., Sundholm, J. K. M., Ojala, T. H., Andersson, S., Sarkola, T.
• Format: Article
• Language: English
• Subjects: abnormal intrauterine growth; Adipose tissue; Age; Area; Birth weight; Body size; Circumferences; echocardiography; fetal; Fetuses; Geometry; Gestation; Gestational age; Heart; Heart valves; Infants; Inflow; large‐for‐gestational age; LGA; Mitral valve; neonatal; Neonates; Newborn babies; Outflow; SGA; Small-for-gestational age; Thorax; Ventricle; Weight
• ISSN: 0960-7692; 1469-0705
• DOI: 10.1002/uog.21972

ABSTRACT Objectives Both excessive and restricted fetal growth are associated with changes in cardiac geometry and function at birth. There are significant issues when indexing cardiac parameters for body size in the neonatal period. The aims of this study were to determine to what extent cardiac geometry is dependent on body size in term and preterm neonates with restricted or excessive fetal growth and how this is affected by adiposity. Methods This was a cross‐sectional study of neonates born between 31 and 42 weeks of gestation, divided into three groups: (1) small‐for‐gestational age (SGA, birth weight > 2 SD below the mean); (2) large‐for‐gestational age (LGA, birth weight > 2 SD above the mean); and (3) appropriate‐for‐gestational‐age controls (AGA, birth weight ≤ 2 SD from the mean). Cardiac geometry and function were compared between the study groups, adjusting for body size. The potential impact of infant adiposity and maternal disease was assessed. Results In total, 174 neonates were included, of which 39 were SGA, 45 were LGA and 90 were AGA. Body size was reflected in cardiac dimensions, with differences in cardiac dimensions disappearing between the SGA and AGA groups when indexed for body surface area (BSA) or thoracic circumference. The same was true for the differences in atrial and ventricular areas between the LGA and AGA groups. However, left ventricular inflow and outflow tract dimensions did not follow this trend as, when indexed for BSA, they were associated negatively with adiposity, resulting in diminished dimensions in LGA compared with AGA and SGA neonates. Adiposity was associated positively with left ventricular mass, right ventricular length and area and right atrial area. The SGA group showed increased right ventricular fractional area change, possibly reflecting differences in the systolic function of the right ventricle. We found evidence of altered diastolic function between the groups, with the mitral valve inflow E‐ to lateral E′‐wave peak velocity ratio being increased in the LGA group and decreased in the SGA group. Conclusions Cardiac geometry is explained by body size in both term and preterm AGA and SGA infants. However, the nature of the relationship between body size and cardiac dimensions may be influenced by adiposity in LGA infants, leading to underestimation of left ventricular inflow and outflow tract dimensions when adjusted for BSA. Adjustments for thoracic circumference provide similar results to those for