In vivo hydroxyapatite scaffold performance in infected bone defects

Critically sized bone defects are often compounded by infectious complications. The standard of care consists of bone autografts with systemic antibiotics. These injuries and treatments lead to donor site morbidity, antibiotic resistant strains of bacteria, and often end stage amputation. This study...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2020-04, Vol.108 (3), p.1157-1166
Main Authors: Pearson, Joseph J., Gerken, Nicholas, Bae, Chunsik, Lee, Kyu‐Bok, Satsangi, Arpan, McBride, Sean, Appleford, Mark R., Dean, David D., Hollinger, Jeffrey O., Ong, Joo L., Guda, Teja
Format: Article
Language:English
Subjects:
Amputation
Antibiotic resistance
Antibiotics
Autografts
Biomedical materials
bone graft
Bone mineral density
calcium phosphate(s)
Complications
Computed tomography
Defects
Euthanasia
Femur
Histology
Hydroxyapatite
infection
Infections
Leukocytes
Materials research
Materials science
Mineralization
Morbidity
Rabbits
Scaffolds
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Summary:Critically sized bone defects are often compounded by infectious complications. The standard of care consists of bone autografts with systemic antibiotics. These injuries and treatments lead to donor site morbidity, antibiotic resistant strains of bacteria, and often end stage amputation. This study proposes an alternative to the autograft using a porous, hydroxyapatite (HA) scaffold evaluated with and without infection and antibiotics. Twenty‐four New Zealand white rabbits received either our HA scaffold or a pulverized autograft (PBA) within a surgically created critical‐sized defect in the femur. The two grafts were evaluated in either septic or aseptic defects and with or without antibiotic treatment. The HA scaffolds were characterized with micro computed tomography. Post‐euthanasia, micro computed tomography, histology, and white blood cells component analysis were completed. The HA had significantly greater (p
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.34466