Perimenopause, body fat, metabolism and menopausal symptoms in relation to serum markers of adiposity, inflammation and digestive metabolism

• Published in: Journal of endocrinological investigation 2020-06, Vol.43 (6), p.809-820
• Main Authors: Palla, G., Ramírez-Morán, C., Montt-Guevara, M. M., Salazar-Pousada, D., Shortrede, J., Simoncini, T., Grijalva-Grijalva, I., Pérez-López, F. R., Chedraui, P.
• Format: Article
• Language: English
• Subjects: Adipose tissue; Adipose Tissue - metabolism; Adiposity - physiology; Angiogenesis; Biomarkers - blood; Blood pressure; Body fat; Body Mass Index; Cholesterol; Cross-Sectional Studies; Digestion - physiology; Endocrinology; Fat metabolism; Female; Ghrelin; Health risk assessment; High density lipoprotein; Hip; Humans; Inflammation; Inflammation Mediators - blood; Insulin; Insulin-like growth factor-binding protein 1; Interleukin 6; Internal Medicine; Leptin; Medicine; Medicine & Public Health; Menopause; Menopause - blood; Metabolic Diseases; Metabolic Diseases - blood; Metabolic Diseases - diagnosis; Metabolic Syndrome - blood; Metabolic Syndrome - diagnosis; Metabolism; Middle Aged; Original Article; Peptides; Perimenopause - blood; Pilot Projects; Serum levels
• ISSN: 1720-8386; 0391-4097; 1720-8386
• DOI: 10.1007/s40618-019-01168-6

Background Perimenopausal women gain weight that may alter inflammatory status, endocrine equilibrium, and the intensity of vasomotor symptoms. Objective To measure serum levels of markers related to adiposity, inflammation/angiogenesis and digestive metabolism and correlate them with body mass index (BMI), waist-to-hip ratio (WHR), metabolic parameters and menopausal symptoms (assessed with the 10-item Cervantes Scale [CS-10]). Methods Serum of perimenopausal women ( n  = 24), STRAW stages-2 and -1, was analyzed using the Bio-Plex 200 System technology to assess 30 proposed analytes. The MetS was defined by the American Heart Association criteria and women were divided as: normal BMI (NBMI), excessive BMI (EBMI), and EBMI with MetS (EBMI–MetS). Results Weight, BMI, abdominal circumference, WHR, systolic blood pressure, glucose and triglyceride levels were significantly higher and high-density lipoprotein cholesterol (HDL-C) was lower in EBMI-MetS women compared to NBMI ones. Insulin, C-peptide, resistin, adipsin, GIP, leptin, IL-6, FGF21 and PAI-1 levels were significantly higher and ghrelin and IGFBP-1 lower in EBMI–MetS women as compared to NBMI ones. Spearman’s correlation of pooled data showed a significant positive correlation between abdominal perimeter and WHR and C-peptide, insulin, adipsin, resistin, leptin, PAI-1 and FGF21 and a negative correlation with IGFBP-1 levels. Total CS-10 scores and hot flush intensity did not differ between studied groups, yet positively correlated with anthropometric values but not with studied analytes. Conclusion Perimenopausal women with EBMI and the MetS showed an altered metabolic profile, but no differences in menopausal symptoms which also did not correlate with changes in studied biomarkers.