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Pressure–impedance analysis: Assist the diagnosis and classification of ineffective esophageal motility disorder
Background and Aim We elucidated the clinical significance of distal contractile integral‐to‐esophageal impedance integral (EII) ratio (DCIIR) in ineffective esophageal motility (IEM) adult patients. Methods We recruited 101 patients with IEM (48.38 ± 1.58 years) and 42 matched healthy volunteers (4...
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| Published in: | Journal of gastroenterology and hepatology 2020-08, Vol.35 (8), p.1317-1324 |
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| container_title | Journal of gastroenterology and hepatology |
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| creator | Wu, Jia‐Feng Tsai, I‐Jung Tong, Tzu‐Wei Lin, Yi‐Cheng Yang, Chia‐Hsiang Tseng, Ping‐Huei |
| description | Background and Aim
We elucidated the clinical significance of distal contractile integral‐to‐esophageal impedance integral (EII) ratio (DCIIR) in ineffective esophageal motility (IEM) adult patients.
Methods
We recruited 101 patients with IEM (48.38 ± 1.58 years) and 42 matched healthy volunteers (44.28 ± 1.85 years) in this case–control study. All subjects underwent esophageal high‐resolution impedance manometry from October 2014 to May 2018. The diagnosis of IEM was based on the Chicago Classification version 3.0. The EII, EII ratio, and DCIIR were analyzed by matlab software.
Results
The EII, EII ratio, and DCIIR calculated at an impedance threshold of 1500 Ω (EII1500, EII ratio1500, and DCIIR1500, respectively) were significantly lower in the IEM group than in healthy controls (P |
| doi_str_mv | 10.1111/jgh.14981 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2337068496</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2337068496</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3531-8f78357fd5474c945b136c7b6a50a13f3a7dc4802b773428d7d50b99e2dfdeb03</originalsourceid><addsrcrecordid>eNp1kc9KxDAQxoMouv45-AIS8KKHatKkTetNRF1F0IOeS5pMdrO0zZq0yt58B9_QJzG6qwfBuQwz85uPYT6E9ik5oTFOZ5PpCeVlQdfQiHJOEip4vo5GpKBZUjJabqHtEGaEEE5Etom2YisVQpAR8g8eQhg8fLy923YOWnYKsOxkswg2nOHzEFOP-ylgbeWkc7GMY41VI-PIWCV76zrsDLYdGAOqty-AIbj5VE5ANrh1vW1sv4j7wXkNfhdtGNkE2FvlHfR0dfl4MU7u7q9vLs7vEsUyRpPCiIJlwuiMC65KntWU5UrUucyIpMwwKbTiBUlrIRhPCy10RuqyhFQbDTVhO-hoqTv37nmA0FetDQqaRnbghlCljAmSF7zMI3r4B525wccnRIozQuJBnEXqeEkp70LwYKq5t630i4qS6suIKhpRfRsR2YOV4lC3oH_Jn89H4HQJvNoGFv8rVbfX46XkJ4UzlDg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2430035343</pqid></control><display><type>article</type><title>Pressure–impedance analysis: Assist the diagnosis and classification of ineffective esophageal motility disorder</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Wu, Jia‐Feng ; Tsai, I‐Jung ; Tong, Tzu‐Wei ; Lin, Yi‐Cheng ; Yang, Chia‐Hsiang ; Tseng, Ping‐Huei</creator><creatorcontrib>Wu, Jia‐Feng ; Tsai, I‐Jung ; Tong, Tzu‐Wei ; Lin, Yi‐Cheng ; Yang, Chia‐Hsiang ; Tseng, Ping‐Huei</creatorcontrib><description><![CDATA[Background and Aim
We elucidated the clinical significance of distal contractile integral‐to‐esophageal impedance integral (EII) ratio (DCIIR) in ineffective esophageal motility (IEM) adult patients.
Methods
We recruited 101 patients with IEM (48.38 ± 1.58 years) and 42 matched healthy volunteers (44.28 ± 1.85 years) in this case–control study. All subjects underwent esophageal high‐resolution impedance manometry from October 2014 to May 2018. The diagnosis of IEM was based on the Chicago Classification version 3.0. The EII, EII ratio, and DCIIR were analyzed by matlab software.
Results
The EII, EII ratio, and DCIIR calculated at an impedance threshold of 1500 Ω (EII1500, EII ratio1500, and DCIIR1500, respectively) were significantly lower in the IEM group than in healthy controls (P < 0.0001, < 0.0001, and < 0.0001, respectively). Receiver operating characteristic analysis showed that DCIIR1500 < 0.008 mmHg/Ω, EII1500 > 71 000 Ω.s.cm, and EII ratio1500 > 0.43 were all predictive of IEM. Only DCIIR1500 < 0.008 mmHg/Ω remained significant in diagnosing IEM in the multivariate logistic regression analysis (odds ratio = 72.13, P < 0.001). The DCIIR1500 is negatively correlated with Eckardt score and the Reflux Disease Questionnaire (correlation coefficient = −0.2844 and −0.3136; P = 0.0006 and 0.0002, respectively). Receiver operating characteristic analysis further showed that a DCIIR1500 cut‐off of 0.002 mmHg/Ω achieved the best differentiation between the IEM‐alternans and IEM‐persistens subtypes among IEM patients (P < 0.001).
Conclusions
The novel pressure–impedance parameter of high‐resolution impedance manometry, DCIIR1500, may assist in the diagnosis and classification of IEM and correlated with clinical symptoms.]]></description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.14981</identifier><identifier>PMID: 31927770</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>bolus transit ; Classification ; Contractility ; Diagnosis ; distal contractile to impedance integral ratio ; esophageal manometry ; Esophagus ; ineffective esophageal motility ; Motility</subject><ispartof>Journal of gastroenterology and hepatology, 2020-08, Vol.35 (8), p.1317-1324</ispartof><rights>2020 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd</rights><rights>2020 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-8f78357fd5474c945b136c7b6a50a13f3a7dc4802b773428d7d50b99e2dfdeb03</citedby><cites>FETCH-LOGICAL-c3531-8f78357fd5474c945b136c7b6a50a13f3a7dc4802b773428d7d50b99e2dfdeb03</cites><orcidid>0000-0002-7483-7538</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31927770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Jia‐Feng</creatorcontrib><creatorcontrib>Tsai, I‐Jung</creatorcontrib><creatorcontrib>Tong, Tzu‐Wei</creatorcontrib><creatorcontrib>Lin, Yi‐Cheng</creatorcontrib><creatorcontrib>Yang, Chia‐Hsiang</creatorcontrib><creatorcontrib>Tseng, Ping‐Huei</creatorcontrib><title>Pressure–impedance analysis: Assist the diagnosis and classification of ineffective esophageal motility disorder</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description><![CDATA[Background and Aim
We elucidated the clinical significance of distal contractile integral‐to‐esophageal impedance integral (EII) ratio (DCIIR) in ineffective esophageal motility (IEM) adult patients.
Methods
We recruited 101 patients with IEM (48.38 ± 1.58 years) and 42 matched healthy volunteers (44.28 ± 1.85 years) in this case–control study. All subjects underwent esophageal high‐resolution impedance manometry from October 2014 to May 2018. The diagnosis of IEM was based on the Chicago Classification version 3.0. The EII, EII ratio, and DCIIR were analyzed by matlab software.
Results
The EII, EII ratio, and DCIIR calculated at an impedance threshold of 1500 Ω (EII1500, EII ratio1500, and DCIIR1500, respectively) were significantly lower in the IEM group than in healthy controls (P < 0.0001, < 0.0001, and < 0.0001, respectively). Receiver operating characteristic analysis showed that DCIIR1500 < 0.008 mmHg/Ω, EII1500 > 71 000 Ω.s.cm, and EII ratio1500 > 0.43 were all predictive of IEM. Only DCIIR1500 < 0.008 mmHg/Ω remained significant in diagnosing IEM in the multivariate logistic regression analysis (odds ratio = 72.13, P < 0.001). The DCIIR1500 is negatively correlated with Eckardt score and the Reflux Disease Questionnaire (correlation coefficient = −0.2844 and −0.3136; P = 0.0006 and 0.0002, respectively). Receiver operating characteristic analysis further showed that a DCIIR1500 cut‐off of 0.002 mmHg/Ω achieved the best differentiation between the IEM‐alternans and IEM‐persistens subtypes among IEM patients (P < 0.001).
Conclusions
The novel pressure–impedance parameter of high‐resolution impedance manometry, DCIIR1500, may assist in the diagnosis and classification of IEM and correlated with clinical symptoms.]]></description><subject>bolus transit</subject><subject>Classification</subject><subject>Contractility</subject><subject>Diagnosis</subject><subject>distal contractile to impedance integral ratio</subject><subject>esophageal manometry</subject><subject>Esophagus</subject><subject>ineffective esophageal motility</subject><subject>Motility</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kc9KxDAQxoMouv45-AIS8KKHatKkTetNRF1F0IOeS5pMdrO0zZq0yt58B9_QJzG6qwfBuQwz85uPYT6E9ik5oTFOZ5PpCeVlQdfQiHJOEip4vo5GpKBZUjJabqHtEGaEEE5Etom2YisVQpAR8g8eQhg8fLy923YOWnYKsOxkswg2nOHzEFOP-ylgbeWkc7GMY41VI-PIWCV76zrsDLYdGAOqty-AIbj5VE5ANrh1vW1sv4j7wXkNfhdtGNkE2FvlHfR0dfl4MU7u7q9vLs7vEsUyRpPCiIJlwuiMC65KntWU5UrUucyIpMwwKbTiBUlrIRhPCy10RuqyhFQbDTVhO-hoqTv37nmA0FetDQqaRnbghlCljAmSF7zMI3r4B525wccnRIozQuJBnEXqeEkp70LwYKq5t630i4qS6suIKhpRfRsR2YOV4lC3oH_Jn89H4HQJvNoGFv8rVbfX46XkJ4UzlDg</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Wu, Jia‐Feng</creator><creator>Tsai, I‐Jung</creator><creator>Tong, Tzu‐Wei</creator><creator>Lin, Yi‐Cheng</creator><creator>Yang, Chia‐Hsiang</creator><creator>Tseng, Ping‐Huei</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7483-7538</orcidid></search><sort><creationdate>202008</creationdate><title>Pressure–impedance analysis: Assist the diagnosis and classification of ineffective esophageal motility disorder</title><author>Wu, Jia‐Feng ; Tsai, I‐Jung ; Tong, Tzu‐Wei ; Lin, Yi‐Cheng ; Yang, Chia‐Hsiang ; Tseng, Ping‐Huei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-8f78357fd5474c945b136c7b6a50a13f3a7dc4802b773428d7d50b99e2dfdeb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>bolus transit</topic><topic>Classification</topic><topic>Contractility</topic><topic>Diagnosis</topic><topic>distal contractile to impedance integral ratio</topic><topic>esophageal manometry</topic><topic>Esophagus</topic><topic>ineffective esophageal motility</topic><topic>Motility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Jia‐Feng</creatorcontrib><creatorcontrib>Tsai, I‐Jung</creatorcontrib><creatorcontrib>Tong, Tzu‐Wei</creatorcontrib><creatorcontrib>Lin, Yi‐Cheng</creatorcontrib><creatorcontrib>Yang, Chia‐Hsiang</creatorcontrib><creatorcontrib>Tseng, Ping‐Huei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Jia‐Feng</au><au>Tsai, I‐Jung</au><au>Tong, Tzu‐Wei</au><au>Lin, Yi‐Cheng</au><au>Yang, Chia‐Hsiang</au><au>Tseng, Ping‐Huei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pressure–impedance analysis: Assist the diagnosis and classification of ineffective esophageal motility disorder</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2020-08</date><risdate>2020</risdate><volume>35</volume><issue>8</issue><spage>1317</spage><epage>1324</epage><pages>1317-1324</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract><![CDATA[Background and Aim
We elucidated the clinical significance of distal contractile integral‐to‐esophageal impedance integral (EII) ratio (DCIIR) in ineffective esophageal motility (IEM) adult patients.
Methods
We recruited 101 patients with IEM (48.38 ± 1.58 years) and 42 matched healthy volunteers (44.28 ± 1.85 years) in this case–control study. All subjects underwent esophageal high‐resolution impedance manometry from October 2014 to May 2018. The diagnosis of IEM was based on the Chicago Classification version 3.0. The EII, EII ratio, and DCIIR were analyzed by matlab software.
Results
The EII, EII ratio, and DCIIR calculated at an impedance threshold of 1500 Ω (EII1500, EII ratio1500, and DCIIR1500, respectively) were significantly lower in the IEM group than in healthy controls (P < 0.0001, < 0.0001, and < 0.0001, respectively). Receiver operating characteristic analysis showed that DCIIR1500 < 0.008 mmHg/Ω, EII1500 > 71 000 Ω.s.cm, and EII ratio1500 > 0.43 were all predictive of IEM. Only DCIIR1500 < 0.008 mmHg/Ω remained significant in diagnosing IEM in the multivariate logistic regression analysis (odds ratio = 72.13, P < 0.001). The DCIIR1500 is negatively correlated with Eckardt score and the Reflux Disease Questionnaire (correlation coefficient = −0.2844 and −0.3136; P = 0.0006 and 0.0002, respectively). Receiver operating characteristic analysis further showed that a DCIIR1500 cut‐off of 0.002 mmHg/Ω achieved the best differentiation between the IEM‐alternans and IEM‐persistens subtypes among IEM patients (P < 0.001).
Conclusions
The novel pressure–impedance parameter of high‐resolution impedance manometry, DCIIR1500, may assist in the diagnosis and classification of IEM and correlated with clinical symptoms.]]></abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31927770</pmid><doi>10.1111/jgh.14981</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7483-7538</orcidid></addata></record> |
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| subjects | bolus transit Classification Contractility Diagnosis distal contractile to impedance integral ratio esophageal manometry Esophagus ineffective esophageal motility Motility |
| title | Pressure–impedance analysis: Assist the diagnosis and classification of ineffective esophageal motility disorder |
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