CC motif chemokine ligand 16 inhibits the progression of liver cirrhosis via inactivating hepatic stellate cells

Liver cirrhosis results from many forms of chronic damage, characterized by accumulation of extracellular matrix. The present study aimed to explore a potential non-invasive biomarker and its mechanism in the progression of liver cirrhosis. Gene Expression Omnibus (GEO) dataset (GSE15654, n = 216) w...

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Bibliographic Details
Published in:Hepatobiliary & pancreatic diseases international 2020-10, Vol.19 (5), p.440-448
Main Authors: Zhuo, Jian-Yong, Lu, Di, Lin, Zu-Yuan, Cen, Bei-Ni, Wei, Xu-Yong, Xie, Hai-Yang, Zheng, Shu-Sen, Xu, Xiao
Format: Article
Language:English
Subjects:
C-C motif chemokine ligand 16
Hepatitis B virus infection
Liver cirrhosis
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Summary:Liver cirrhosis results from many forms of chronic damage, characterized by accumulation of extracellular matrix. The present study aimed to explore a potential non-invasive biomarker and its mechanism in the progression of liver cirrhosis. Gene Expression Omnibus (GEO) dataset (GSE15654, n = 216) was analyzed to screen genes associated with progression of liver cirrhosis. A total of 181 plasma samples, including healthy control (HC, n = 20), chronic hepatitis B (CHB, n = 77) and HBV-related liver cirrhosis (LC, n = 84), were enrolled for validation. In vitro and in vivo experiments were employed for the mechanistic investigation. GEO dataset analysis showed that relatively low mRNA-expression of CC motif chemokine ligand 16 (CCL16) was associated with elevated Child-Pugh score (P = 0.034) and worse prognosis (P = 0.025). Plasma CCL16 level decreased in a stepwise pattern, with a median concentration of 10.29, 6.57 and 4.47 ng/mL in the HC, CHB and LC groups, respectively (P
ISSN:1499-3872
DOI:10.1016/j.hbpd.2019.12.006