Palhinosides A–H: Flavone Glucosidic Truxinate Esters with Neuroprotective Activities from Palhinhaea cernua

Palhinosides A–H (1–8), new flavone glucosidic truxinate esters, including β-truxinate and μ-truxinate forms, were isolated from Palhinhaea cernua. Their structures were elucidated by extensive spectroscopic methods and chemical analyses. The flavone glucoside cyclodimers possess a unique cyclobutan...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2020-02, Vol.83 (2), p.216-222
Main Authors: Li, Jing, Tan, Lei-Hong, Zou, Hui, Zou, Zhen-Xing, Long, Hong-Ping, Wang, Wen-Xuan, Xu, Ping-Sheng, Liu, Li-Fei, Xu, Kang-Ping, Tan, Gui-Shan
Format: Article
Language:English
Subjects:
Esters
Flavones - chemistry
Flavones - isolation & purification
Glucosides
Lycopodiaceae - chemistry
Molecular Structure
Neuroprotective Agents
Triterpenes - chemistry
Triterpenes - isolation & purification
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Summary:Palhinosides A–H (1–8), new flavone glucosidic truxinate esters, including β-truxinate and μ-truxinate forms, were isolated from Palhinhaea cernua. Their structures were elucidated by extensive spectroscopic methods and chemical analyses. The flavone glucoside cyclodimers possess a unique cyclobutane ring in their carbon scaffolds. Compounds 2–7 represent three pairs of stereoisomers (2/3, 4/5, 6/7). The protective effects of 1–8 against the damage of HT-22 cells induced by l-glutamate were evaluated, and compounds 4 and 5 showed better neuroprotective effects than the positive control, Trolox.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.9b00470