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Spleen size improvement in advanced heart failure patients using a left ventricular assist device

The spleen has been recognized as an important organ that holds a reserve of 20% to 30% of the total blood volume. Spleen contraction and splenic volume reduction occur in patients with hypovolemic shock. However, the change in the spleen volume and the association between spleen size and hemodynami...

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Bibliographic Details
Published in:Artificial organs 2020-07, Vol.44 (7), p.700-708
Main Authors: Hiraiwa, Hiroaki, Okumura, Takahiro, Sawamura, Akinori, Kondo, Toru, Kazama, Shingo, Kimura, Yuki, Shibata, Naoki, Arao, Yoshihito, Oishi, Hideo, Kato, Hiroo, Kuwayama, Tasuku, Yamaguchi, Shogo, Furusawa, Kenji, Morimoto, Ryota, Murohara, Toyoaki
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Language:English
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Summary:The spleen has been recognized as an important organ that holds a reserve of 20% to 30% of the total blood volume. Spleen contraction and splenic volume reduction occur in patients with hypovolemic shock. However, the change in the spleen volume and the association between spleen size and hemodynamic parameters remain unclear in patients with advanced heart failure (HF) who need left ventricular assist device (LVAD) support. This study was performed to investigate the change in spleen size and the relationship between spleen size and hemodynamic parameters before and after LVAD implantation in patients with advanced HF. We enrolled 20 patients with advanced HF on LVAD support. All patients underwent right heart catheterization and computed tomography before and after LVAD implantation. The spleen size was measured by computed tomography volumetry. We excluded patients with a mean right atrial pressure (RAP) of 2.2 L/min/m2 before LVAD implantation. The splenic volume significantly increased from 160.6 ± 46.9 mL before LVAD implantation to 224.6 ± 73.5 mL after LVAD implantation (P 
ISSN:0160-564X
1525-1594
DOI:10.1111/aor.13658