Andrographolide mitigates cardiac apoptosis to provide cardio‐protection in high‐fat‐diet‐induced obese mice

Excessive intake of high fat diet (HFD) and associated obese conditions are critical contributors of cardiac diseases. In this study, an active metabolite andrographolide from Andrographis paniculata was found to ameliorate HFD‐induced cardiac apoptosis. C57/BL6 mouse were grouped as control (n = 9)...

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Published in:Environmental toxicology 2020-06, Vol.35 (6), p.707-713
Main Authors: Lin, Kuan‐Ho, Marthandam Asokan, Shibu, Kuo, Wei‐Wen, Hsieh, You‐Liang, Lii, Chong‐Kuei, Viswanadha, Vijayapadma, Lin, Yi‐Lin, Wang, Shulin, Yang, Caixian, Huang, Chih‐Yang
Format: Article
Language:English
Subjects:
Andrographis paniculata
Apoptosis
cardiac apoptosis
Cardiovascular diseases
cell survival
Coronary artery disease
Diet
Dietary supplements
Health services
Heart diseases
High fat diet
Histopathology
Insulin-like growth factors
Medical treatment
Metabolites
obesity
Proteins
Survival
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Summary:Excessive intake of high fat diet (HFD) and associated obese conditions are critical contributors of cardiac diseases. In this study, an active metabolite andrographolide from Andrographis paniculata was found to ameliorate HFD‐induced cardiac apoptosis. C57/BL6 mouse were grouped as control (n = 9), obese (n = 8), low dose (25 mg/kg/d) andrographolide treatment (n = 9), and high dose (50 mg/kg/d) andrographolide treatment (n = 9). The control group was provided with standard laboratory chow and the other groups were fed with HFD. Andrographolide was administered through oral gavage for 1 week. Histopathological analysis showed increase in apoptotic nuclei and considerable cardiac‐damages in the obese group signifying cardiac remodeling effects. Further, Western blot results showed increase in pro‐apoptotic proteins and decrease in the proteins of IGF‐1R‐survival signaling. However, feeding of andrographolide significantly reduced the cardiac effects of HFD. The results strongly suggest that andrographolide supplementation can be used for prevention and treatment of cardiovascular disease in obese patients.
ISSN:1520-4081
1522-7278
DOI:10.1002/tox.22906