Synthesis of 7′-Arylidenespiro[indoline-3,1′-pyrrolizines] and 7′-Arylidenespiro[indene-2,1′-pyrrolizines] via [3 + 2] Cycloaddition and β‑C–H Functionalized Pyrrolidine

The acetic acid catalyzed three-component reaction of pyrrolidine, aromatic aldehydes, and 3-arylideneoxindolin-2-ones in refluxing toluene afforded functionalized 7′-arylidenespiro­[indoline-3,1′-pyrrolizines] in good yields and with high diastereoselectivity. The similar three-component reaction w...

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Bibliographic Details
Published in:Journal of organic chemistry 2019-10, Vol.84 (19), p.12437-12451
Main Authors: Huang, Ying, Fang, Hui-Lin, Huang, Yi-Xin, Sun, Jing, Yan, Chao-Guo
Format: Article
Language:English
Subjects:
acetic acid
aldehydes
catalytic activity
chemical structure
colorectal neoplasms
cycloaddition reactions
diastereoselectivity
in vitro studies
liver neoplasms
mice
neoplasm cells
reaction mechanisms
toluene
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