Postoperative Complications have Minimal Impact on Long-Term Prognosis in Immunodeficient Patients with Esophageal Cancer

Background Postoperative complications have been recognized to have an adverse prognostic impact in various types of cancer. However, in a recent study, it has been reported that postoperative complications of total gastrectomy with splenectomy have little impact on the long-term outcomes of patient...

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Bibliographic Details
Published in:Annals of surgical oncology 2020-08, Vol.27 (8), p.3064-3070
Main Authors: Maruyama, Suguru, Kawaguchi, Yoshihiko, Akaike, Hidenori, Shoda, Katsutoshi, Saito, Ryo, Shimizu, Hiroki, Furuya, Shinji, Hosomura, Naohiro, Amemiya, Hidetake, Kawaida, Hiromichi, Sudo, Makoto, Inoue, Shingo, Kono, Hiroshi, Ichikawa, Daisuke
Format: Article
Language:English
Subjects:
Cell number
Esophageal cancer
Esophageal Neoplasms - surgery
Esophagectomy - adverse effects
Esophagus
Gastrectomy
Gastrectomy - adverse effects
Gastric cancer
Humans
Immunodeficiency
Immunosuppression
Lymphocytes
Medical prognosis
Medicine
Medicine & Public Health
Oncology
Postoperative Complications - etiology
Postoperative period
Prognosis
Retrospective Studies
Splenectomy
Stomach Neoplasms - surgery
Surgery
Surgical Oncology
Survival Rate
Thoracic Oncology
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Summary:Background Postoperative complications have been recognized to have an adverse prognostic impact in various types of cancer. However, in a recent study, it has been reported that postoperative complications of total gastrectomy with splenectomy have little impact on the long-term outcomes of patients with gastric cancer. In addition, the mechanisms underlying the effect of postoperative complications on outcomes remain to be elucidated. We hypothesized that immunosuppression by postoperative complications may affect long-term outcomes in patients with esophageal cancer. Methods In this retrospective study, we assessed in 153 patients with esophageal cancer who underwent curative subtotal esophagectomy at our hospital and examined the correlation between postoperative complications, and multiple clinicopathological factors, and long-term outcomes with the patients stratified by total lymphocyte count (TLC). Results The median preoperative TLC was 1432. A total of 115 patients (75.2%) had a TLC of ≥ 1000/μL (high TLC group), and the remaining 38 patients (24.8%) had a TLC of
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-020-08245-8