Modulation of Interfacial Hydration by Carbonyl Groups in Lipid Membranes

The lack of carbonyl groups and the presence of ether bonds give the lipid interphase a different water organization around the phosphate groups that affects the compressibility and electrical properties of lipid membranes. Generalized polarization of 1,2-di-O-tetradecyl-sn-glycero-3-phosphocholine...

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Bibliographic Details
Published in:Langmuir 2020-03, Vol.36 (10), p.2644-2653
Main Authors: Pérez, H. A, Cejas, J. P, Rosa, A. S, Giménez, R. E, Disalvo, E. A, Frías, M. A
Format: Article
Language:English
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Summary:The lack of carbonyl groups and the presence of ether bonds give the lipid interphase a different water organization around the phosphate groups that affects the compressibility and electrical properties of lipid membranes. Generalized polarization of 1,2-di-O-tetradecyl-sn-glycero-3-phosphocholine (14:0 diether PC) in correlation with Fourier transform infrared (FTIR) analysis indicates a higher level of polarizability of water molecules in the membrane phase around the phosphate groups both below and above T m. This reorganization of water promotes a different response in compressibility and dipole moment of the interphase, which is related to different H bonding of water molecules with phosphates (PO) and carbonyl (CO) groups.
ISSN:0743-7463
1520-5827
DOI:10.1021/acs.langmuir.9b03551